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D Sekula

Explore the profile of D Sekula including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 128
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Recent Articles
1.
Feng Q, Sekula D, Muller R, Freemantle S, Dmitrovsky E
Oncogene . 2007 Feb; 26(35):5098-106. PMID: 17310991
Cyclin D1 regulates G1 cell-cycle progression and is aberrantly expressed in carcinogenesis. Proteasomal degradation of cyclin D1 was highlighted as a cancer chemopreventive mechanism. To understand this mechanism better, residues...
2.
Curtin J, Dragnev K, Sekula D, Christie A, Dmitrovsky E, Spinella M
Oncogene . 2001 Jun; 20(20):2559-69. PMID: 11420666
Although retinoids are known to regulate gene transcription by activating retinoid receptors, the targets of retinoid receptors are largely unknown. This study indicates effective all-trans retinoic acid (RA)-induced differentiation of...
3.
Spinella M, Freemantle S, Sekula D, Chang J, Christie A, Dmitrovsky E
J Biol Chem . 1999 Jul; 274(31):22013-8. PMID: 10419526
Mechanisms by which differentiation programs engage the cell cycle are poorly understood. This study demonstrates that retinoids promote ubiquitination and degradation of cyclin D1 during retinoid-induced differentiation of human embryonal...
4.
Boyle J, Langenfeld J, Lonardo F, Sekula D, Reczek P, Rusch V, et al.
J Natl Cancer Inst . 1999 Mar; 91(4):373-9. PMID: 10050872
Background: Retinoids (derivatives of vitamin A) are reported to reduce the occurrence of some second primary cancers, including aerodigestive tract tumors. In contrast, beta-carotene does not reduce the occurrence of...
5.
Spinella M, Kitareewan S, Mellado B, Sekula D, Khoo K, Dmitrovsky E
Oncogene . 1998 Aug; 16(26):3471-80. PMID: 9692555
This study addresses the contributions of specific retinoid receptors during all-trans-retinoic acid (RA)-mediated differentiation and growth suppression of human embryonal carcinoma cells. The pleiotropic effects of RA are mediated by...
6.
Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E
Proc Natl Acad Sci U S A . 1997 Oct; 94(22):12070-4. PMID: 9342364
The retinoids are reported to reduce incidence of second primary aerodigestive cancers. Mechanisms for this chemoprevention are previously linked to all-trans retinoic acid (RA) signaling growth inhibition at G1 in...