D Scott Edwards
Overview
Explore the profile of D Scott Edwards including associated specialties, affiliations and a list of published articles.
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29
Citations
757
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Recent Articles
1.
Askew B, Furuya T, Edwards D
J Pharmacol Exp Ther
. 2018 Jun;
366(2):244-250.
PMID: 29853477
SF0166, a small-molecule antagonist, has physiochemical properties that allow distribution to the posterior segment of the eye after topical administration in an ophthalmic solution. The pharmacodynamics and ocular distribution of...
2.
Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki L, et al.
Arterioscler Thromb Vasc Biol
. 2010 Oct;
31(1):102-9.
PMID: 20947820
Objective: To establish and validate early noninvasive imaging of matrix metalloproteinase (MMP) activation for monitoring the progression of vascular remodeling and response to dietary modification. Methods And Results: Apolipoprotein E(-/-)...
3.
Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki L, et al.
J Nucl Med
. 2010 Jun;
51(7):1107-15.
PMID: 20554725
Unlabelled: Rupture and dissection are major causes of morbidity and mortality in arterial aneurysm and occur more frequently in rapidly expanding aneurysms. Current imaging modalities provide little information on aneurysm...
4.
Ohshima S, Fujimoto S, Petrov A, Nakagami H, Haider N, Zhou J, et al.
J Am Coll Cardiol
. 2010 Mar;
55(12):1240-1249.
PMID: 20298932
Objectives: Technetium-99m-labeled matrix metalloproteinase inhibitor (MPI) was used for the noninvasive assessment of matrix metalloproteinase (MMP) activity in atherosclerotic plaques after minocycline (MC) intervention. Background: MMP activity in atherosclerosis contributes...
5.
Ohshima S, Petrov A, Fujimoto S, Zhou J, Azure M, Edwards D, et al.
J Nucl Med
. 2009 Mar;
50(4):612-7.
PMID: 19289429
Unlabelled: Matrix metalloproteinases (MMPs) are expressed in atherosclerotic plaques and play an important role in plaque instability. Methods: Using (99m)Tc-labeled broad-spectrum MMP inhibitor (MPI), we performed noninvasive imaging of MMP...
6.
Fujimoto S, Hartung D, Ohshima S, Edwards D, Zhou J, Yalamanchili P, et al.
J Am Coll Cardiol
. 2008 Nov;
52(23):1847-1857.
PMID: 19038682
Objectives: This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis using technetium-99m-labeled broad matrix metalloproteinase inhibitor (MPI) and to determine the...
7.
Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki L, Asadi A, et al.
Circulation
. 2008 Oct;
118(19):1953-60.
PMID: 18936327
Background: Matrix metalloproteinase (MMP) activation plays a key role in vascular remodeling. RP782 is a novel indium (111)In-labeled tracer with specificity for activated MMPs. We hypothesized that RP782 can detect...
8.
Harris T, Cheesman E, Harris A, Sachleben R, Edwards D, Liu S, et al.
Bioconjug Chem
. 2007 Jun;
18(4):1266-79.
PMID: 17579472
The integrin receptor alphavbeta3 is overexpressed on the endothelial cells of growing tumors and on some tumor cells themselves. A radiolabeled alphavbeta3 antagonists belonging to the quinolin-4-one class of peptidomimetics...
9.
Harris T, Kalogeropoulos S, Nguyen T, Dwyer G, Edwards D, Liu S, et al.
Bioconjug Chem
. 2006 Sep;
17(5):1294-313.
PMID: 16984141
The integrin receptor alpha(v)beta(3) is overexpressed on the endothelial cells of growing tumors and on some tumor cells themselves. Radiolabeled alpha(v)beta(3) antagonists have demonstrated potential application as tumor imaging agents...
10.
Su H, Spinale F, Dobrucki L, Song J, Hua J, Sweterlitsch S, et al.
Circulation
. 2005 Nov;
112(20):3157-67.
PMID: 16275862
Background: Time-dependent activation of matrix metalloproteinases (MMPs) after myocardial infarction (MI) contributes to adverse left ventricular (LV) remodeling; however, noninvasive methods to monitor this process serially are needed. Methods And...