D S Linthicum
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Explore the profile of D S Linthicum including associated specialties, affiliations and a list of published articles.
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113
Citations
606
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Recent Articles
1.
Droupadi P, Nanavaty T, Smith C, Johnson D, Adamczyk M, Linthicum D
J Fluoresc
. 2013 Nov;
5(3):273-7.
PMID: 24226794
Two mouse anti-fluorescyl monoclonal antibodies (mAb), clones FL43.1 and FL55.3, were produced to the fluorescein hapten, which was conjugated to the carrier protein through the 4' position of the xanthene...
2.
Linthicum D
Tissue Cell
. 2002 Apr;
33(5):514-23.
PMID: 11949787
Transmission and scanning electron microscopic examination of primary lung fibroblasts exposed in tissue culture to polymeric silicic acid (PSA) revealed profound cellular changes in the cell surface membranes, resulting in...
3.
Linthicum D, Tetin S, Anchin J, Ioerger T
Comb Chem High Throughput Screen
. 2001 Jul;
4(5):439-49.
PMID: 11472232
Several new aspects of computer-assisted molecular modeling strategies and biophysical techniques, such as fluorescence spectroscopy, circular dichroism, and absorption spectroscopy, have proved useful in the analysis and description of antibody-ligand...
4.
Linthicum D, Patel J, Cairns N
Comb Chem High Throughput Screen
. 2001 Jul;
4(5):431-8.
PMID: 11472231
Technological advances in instrumentation, chemical synthesis methods, molecular biology and biochemistry have fueled the recent growth in high throughput screening. Assays are available in a vast range for formats, including...
5.
Hofle M, Linthicum D, Ioerger T
Mol Immunol
. 2001 Mar;
37(14):827-35.
PMID: 11257304
Nucleotide fill-in between the germ line V, D and J genes in the H3 loop of immunoglobulins contributes to the diversity of the antibody repertoire. This fill-in process is mediated...
6.
Zhang A, Khare S, Gokulan K, Linthicum D, Burgess K
Bioorg Med Chem Lett
. 2001 Feb;
11(2):207-10.
PMID: 11206460
Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the...
7.
Khare S, Gokulan K, Linthicum D
J Neurosci Res
. 2001 Feb;
63(1):64-71.
PMID: 11169615
The Cytosensor microphysiometer device (Molecular Devices, Sunnyvale, CA) is capable of detecting small changes in cellular metabolism in response to specific bioactive ligands by measuring the extracellular acidification rate (ECAR)....
8.
Modiano J, Mayor J, Ball C, Fuentes M, Linthicum D
J Immunol
. 2000 Dec;
165(12):6693-702.
PMID: 11120786
Stimulation of lymphocytes through the Ag receptor can lead to cytokine responsiveness or unresponsiveness. We examined the importance of cyclin-dependent kinase (CDK)4 to establish and maintain IL-2 responsiveness in human...
9.
Guddat L, Shan L, Broomell C, Ramsland P, Fan Z, Anchin J, et al.
J Mol Biol
. 2000 Sep;
302(4):853-72.
PMID: 10993728
The three-dimensional structure of a complex of an Fab from a murine IgG2b(lambda) antibody (NC10.14) with a high potency sweet tasting hap- ten, N-(p-cyanophenyl)-N'-(diphenylmethyl)-N"-(carboxymethyl)guan idine (NC174), has been determined to...
10.
Khare S, Gokulan K, Linthicum D
J Neurosci Res
. 2000 May;
60(3):356-61.
PMID: 10797538
The Cytosensortrade mark microphysiometer device is capable detecting cellular responses to specific bioactive ligands by measuring the extracellular acidification rate (ECAR). Using microphysiometry, we were able to determine that cerebovascular...