D R Roop
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Explore the profile of D R Roop including associated specialties, affiliations and a list of published articles.
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154
Citations
4369
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Recent Articles
1.
Yang N, Leung E, Liu C, Li L, Eguether T, Jun Yao X, et al.
Oncogene
. 2017 May;
36(35):4997-5005.
PMID: 28459465
Inturned (INTU), a cilia and planar polarity effector, performs prominent ciliogenic functions during morphogenesis, such as in the skin. INTU is expressed in adult tissues but its role in tissue...
2.
Morton J, Bird G, Keysar S, Astling D, Lyons T, Anderson R, et al.
Oncogene
. 2015 Apr;
35(3):290-300.
PMID: 25893296
The limitations of cancer cell lines have led to the development of direct patient-derived xenograft models. However, the interplay between the implanted human cancer cells and recruited mouse stromal and...
3.
Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma
Torchia E, Caulin C, Acin S, Terzian T, Kubick B, Box N, et al.
Oncogene
. 2011 Oct;
31(21):2680-90.
PMID: 21963848
Clinical observations, as well as data obtained from the analysis of genetically engineered mouse models, firmly established the gain-of-function (GOF) properties of certain p53 mutations. However, little is known about...
4.
Bu W, Chen J, Morrison G, Huang S, Creighton C, Huang J, et al.
Oncogene
. 2011 May;
30(43):4399-409.
PMID: 21532625
Progenitor cells are considered an important cell of origin of human malignancies. However, there has not been any single gene that can define mammary bipotential progenitor cells, and as such...
5.
Mikkola M, Costanzo A, Thesleff I, Roop D, Koster M
Cell Death Differ
. 2009 Oct;
17(1):180-3.
PMID: 19876067
No abstract available.
6.
Honeycutt K, Chen Z, Koster M, Miers M, Nuchtern J, Hicks J, et al.
Oncogene
. 2006 Mar;
25(29):4027-32.
PMID: 16518415
Minichromosomal maintenance protein 7 (MCM7) is an essential component of the replication helicase complex (MCM2-7) required for DNA replication. Although this function is highly conserved among eukaryotes, additional functions for...
7.
Arin M, Roop D
Trends Mol Med
. 2001 Sep;
7(9):422-4.
PMID: 11530338
Hereditary skin blistering disorders comprise a group of genodermatoses whose common primary feature is the formation of blisters following minor trauma. Examples of such conditions include epidermolysis bullosa and several...
8.
Wojcik S, Longley M, Roop D
J Cell Biol
. 2001 Aug;
154(3):619-30.
PMID: 11489919
The murine genome is known to have two keratin 6 (K6) genes, mouse K6 (MK6)a and MK6b. These genes display a complex expression pattern with constitutive expression in the epithelia...
9.
Long 2nd D, Waikel R, Wang X, Roop D, Jaiswal A
J Natl Cancer Inst
. 2001 Aug;
93(15):1166-70.
PMID: 11481389
Background: The phase II enzyme NAD(P)H :quinone oxidoreductase 1 (NQO1) catalyzes quinone detoxification, protecting cells from redox cycling, oxidative stress, mutagenicity, and cytotoxicity induced by quinones and its precursors. We...
10.
Waikel R, Kawachi Y, Waikel P, Wang X, Roop D
Nat Genet
. 2001 May;
28(2):165-8.
PMID: 11381265
The beta-catenin/TCF signaling pathway is essential for the maintenance of epithelial stem cells in the small intestine. c-Myc a downstream target of beta-catenin/TCF (ref. 2), can induce differentiation of epidermal...