D R Roop
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Explore the profile of D R Roop including associated specialties, affiliations and a list of published articles.
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154
Citations
4369
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Recent Articles
11.
Cao T, Longley M, Wang X, Roop D
J Cell Biol
. 2001 Feb;
152(3):651-6.
PMID: 11157990
The Dowling-Meara variant of epidermolysis bullosa simplex (EBS-DM) is a severe blistering disease inherited in an autosomal-dominant fashion. Here we report the generation of a mouse model that allows focal...
12.
Arin M, Longley M, Wang X, Roop D
J Cell Biol
. 2001 Feb;
152(3):645-9.
PMID: 11157989
Stem cells are crucial for the formation and maintenance of tissues and organs. The role of stem cells in the pathogenesis of mosaic skin disorders remains unclear. To study the...
13.
Long 2nd D, Waikel R, Wang X, Perlaky L, Roop D, Jaiswal A
Cancer Res
. 2000 Nov;
60(21):5913-5.
PMID: 11085502
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. C57BL6 NQO1-/- mice,...
14.
Cao T, Wang X, Roop D
Hum Gene Ther
. 2000 Nov;
11(16):2297-300.
PMID: 11084689
Epidermal keratinocytes can secrete polypeptides into the bloodstream, and they can be easily expanded in culture and genetically modified. It is thus possible to use epidermal keratinocytes for the systemic...
15.
Wang X, Greenhalgh D, Donehower L, Roop D
Mol Carcinog
. 2000 Nov;
29(2):67-75.
PMID: 11074603
To investigate the role of loss of the p53 tumor suppressor gene in skin carcinogenesis, p53 knockout (p53(-/-)) mice were mated with transgenic mice coexpressing v-Ha-ras, v-fos, or human transforming...
16.
Suga Y, Jarnik M, Attar P, Longley M, Bundman D, Steven A, et al.
J Cell Biol
. 2000 Oct;
151(2):401-12.
PMID: 11038186
Mutations in the cornified cell envelope protein loricrin have been reported recently in some patients with Vohwinkel syndrome (VS) and progressive symmetric erythrokeratoderma (PSEK). To establish a causative relationship between...
17.
Koch P, de Viragh P, Scharer E, Bundman D, Longley M, Bickenbach J, et al.
J Cell Biol
. 2000 Oct;
151(2):389-400.
PMID: 11038185
The epidermal cornified cell envelope (CE) is a complex protein-lipid composite that replaces the plasma membrane of terminally differentiated keratinocytes. This lamellar structure is essential for the barrier function of...
18.
Liefer K, Koster M, Wang X, Yang A, McKeon F, Roop D
Cancer Res
. 2000 Aug;
60(15):4016-20.
PMID: 10945600
In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal...
19.
Wojcik S, Bundman D, Roop D
Mol Cell Biol
. 2000 Jun;
20(14):5248-55.
PMID: 10866680
Keratin 6 (K6) expression in the epidermis has two components: constitutive expression in the innermost layer of the outer root sheath (ORS) of hair follicles and inducible expression in the...
20.
Berton T, Wang X, Zhou Z, Kellendonk C, Schutz G, Tsai S, et al.
Genesis
. 2000 Mar;
26(2):160-1.
PMID: 10686618
No abstract available.