D R Meldrum
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Explore the profile of D R Meldrum including associated specialties, affiliations and a list of published articles.
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199
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2526
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Recent Articles
1.
Yaron J, Gangaraju S, Rao M, Kong X, Zhang L, Su F, et al.
Cell Death Dis
. 2015 Oct;
6:e1954.
PMID: 26512962
P2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS-primed macrophages. The role of potassium and calcium in...
2.
Meldrum D, Gambone J, Morris M, Esposito K, Giugliano D, Ignarro L
Int J Impot Res
. 2011 Nov;
24(2):61-8.
PMID: 22072232
Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been...
3.
Meldrum K, Misseri R, Metcalfe P, Dinarello C, Hile K, Meldrum D
Am J Physiol Regul Integr Comp Physiol
. 2006 Dec;
292(4):R1456-64.
PMID: 17170233
Upper urinary tract obstruction results in tubulointerstitial fibrosis and a progressive decline in renal function. Although several inflammatory mediators have been implicated in the pathophysiology of renal obstruction, the contribution...
4.
Misseri R, Meldrum D, Dinarello C, Dagher P, Hile K, Rink R, et al.
Am J Physiol Renal Physiol
. 2004 Oct;
288(2):F406-11.
PMID: 15507546
Obstruction of the upper urinary tract induces a progressive loss in renal mass through apoptotic renal cell death. Although TNF-alpha has been implicated in ischemia-reperfusion-induced apoptotic renal cell death, its...
5.
Meldrum K, Hile K, Meldrum D, Crone J, Gearhart J, Burnett A
J Urol
. 2002 Jun;
168(1):248-52.
PMID: 12050551
Purpose: Ischemia-reperfusion injury is a relatively common cause of renal tubular cell death and acute renal failure. While nuclear factor-kappaB has been implicated in the pathophysiology of renal ischemia-reperfusion injury,...
6.
Raeburn C, Moore E, Biffl W, Johnson J, Meldrum D, Offner P, et al.
Am J Surg
. 2002 Feb;
182(6):542-6.
PMID: 11839314
Background: The abdominal compartment syndrome (ACS) is a recognized complication of damage control surgery (DCS). The purposes of this study were to (1) determine the effect of ACS on outcome...
7.
Meldrum K, Meldrum D, Hile K, Burnett A, Harken A
J Surg Res
. 2001 Jul;
99(2):288-93.
PMID: 11469899
Purpose: Renal ischemia-reperfusion (IR) injury is a devastating clinical problem. While effective animal models have been developed to investigate this condition, they are limited by differential renal cell inflammatory mediator...
8.
Meldrum K, Meldrum D, Hile K, Yerkes E, Ayala A, Cain M, et al.
Am J Physiol Cell Physiol
. 2001 Jul;
281(2):C563-70.
PMID: 11443055
Ischemia causes renal tubular cell loss through apoptosis; however, the mechanisms of this process remain unclear. Using the renal tubular epithelial cell line LLC-PK(1), we developed a model of simulated...
9.
Meldrum K, Meldrum D, Sezen S, Crone J, Burnett A
Am J Physiol Regul Integr Comp Physiol
. 2001 Jun;
281(1):R359-64.
PMID: 11404313
Heat shock produces cellular tolerance to a variety of adverse conditions; however, the protective effect of heat shock on renal cell ischemic injury remains unclear. Protein kinase C (PKC) has...
10.