D Nemazee
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Explore the profile of D Nemazee including associated specialties, affiliations and a list of published articles.
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50
Citations
1956
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Recent Articles
1.
Nemazee D, Gavin A, Hoebe K, Beutler B
Nature
. 2006 May;
441(7091):E4.
PMID: 16710369
Microbial components, such as lipopolysaccharides, augment immune responses by activating Toll-like receptors (TLRs). Some have interpreted this to mean that TLR signalling might not only help to initiate the adaptive...
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Kouskoff V, Nemazee D
Life Sci
. 2001 Aug;
69(10):1105-13.
PMID: 11508343
B and T lymphocytes that carry antigen receptors are able to change specificity through subsequent receptor gene rearrangements. Receptor editing and receptor revision are terms used to distinguish those rearrangements...
4.
Casellas R, Shih T, Kleinewietfeld M, Rakonjac J, Nemazee D, Rajewsky K, et al.
Science
. 2001 Feb;
291(5508):1541-4.
PMID: 11222858
Receptor editing, clonal deletion, and anergy are the mechanisms by which B cells maintain tolerance to self antigens. To determine the extent to which receptor editing shapes the normal antibody...
5.
Buhl A, Nemazee D, Cambier J, Rickert R, Hertz M
Immunol Rev
. 2000 Oct;
176:141-53.
PMID: 11043774
Experimental evidence contradicts the simplistic view that during development all B cells expressing non autoreactive antigen receptors on the cell surface are selected into the mature B-cell pool. While allelic...
6.
Melamed D, Miri E, Leider N, Nemazee D
J Immunol
. 2000 Oct;
165(8):4353-8.
PMID: 11035071
In the B lymphocyte lineage, Fas-mediated cell death is important in controlling activated mature cells, but little is known about possible functions at earlier developmental stages. In this study we...
7.
Nemazee D
Immunol Res
. 2000 Jun;
21(2-3):259-63.
PMID: 10852126
B lymphocytes learn through the interaction of the B cell receptor with antigens in the context of B cell developmental stage and environmental cues. B cells can respond by proliferation...
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Nemazee D
Annu Rev Immunol
. 2000 Jun;
18:19-51.
PMID: 10837051
The process of clonal selection is a central feature of the immune system, but immune specificity is also regulated by receptor selection, in which the fate of a lymphocyte's antigen...
10.
Kouskoff V, Lacaud G, Pape K, Retter M, Nemazee D
Proc Natl Acad Sci U S A
. 2000 Jun;
97(13):7435-9.
PMID: 10829082
During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and...