D N Wheatley
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Explore the profile of D N Wheatley including associated specialties, affiliations and a list of published articles.
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155
Citations
1292
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Recent Articles
1.
Lam T, Wong G, Chong H, Cheng P, Choi S, Chow T, et al.
Cancer Lett
. 2009 Jan;
277(1):91-100.
PMID: 19138817
Human hepatocellular carcinoma (HCC) has an elevated requirement for arginine in vitro, and pegylated recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors. While...
2.
Matveev V, Wheatley D
Cell Mol Biol (Noisy-le-grand)
. 2005 Dec;
51(8):797-801.
PMID: 16359629
The last 50 years in the history of life sciences are remarkable for a new important feature that looks as a great threat for their future. A profound specialization dominating...
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4.
Bishop E, Bell G, Bloor S, Broom I, Hendry N, Wheatley D
Angiogenesis
. 2003 Oct;
3(4):335-44.
PMID: 14517413
This report describes a model of angiogenesis which develops in admixtures (co-cultures) of human umbilical vein endothelial cells (HUVEC) and human diploid fibroblasts of dermal origin from adult patients. The...
5.
Park I, Kang S, Shin Y, Chae K, Park M, Kim M, et al.
Br J Cancer
. 2003 Aug;
89(5):907-14.
PMID: 12942125
Hydrolysis of plasma arginine to citrulline by arginine deiminase (ADI) was recently shown to suppress lipopolysaccharide-induced nitric oxide (NO) synthesis. Since arginine is the precursor of NO, and the latter...
6.
Wheatley D, Campbell E
Br J Cancer
. 2003 Jul;
89(3):573-6.
PMID: 12888832
Arginine deprivation causes death of up to 80% of cancer cell lines in vitro, but in the body, citrulline would be available as a convertible source of this amino acid...
7.
Philip R, Campbell E, Wheatley D
Br J Cancer
. 2003 Feb;
88(4):613-23.
PMID: 12592378
Arginase added to culture medium reduced arginine to negligible levels within approximately 6 h, and enzyme activity persisted relatively undiminished for at least 3 days. Human and bovine arginase proved...
8.
Agutter P, Malone P, Wheatley D
J Hist Biol
. 2001 Oct;
33(1):71-111.
PMID: 11624418
Diffusion theory explains in physical terms how materials move through a medium, e.g. water or a biological fluid. There are strong and widely acknowledged grounds for doubting the applicability of...
9.
MUIR I, Wheatley D, Eremin O
Cell Biol Int
. 2001 Jul;
25(7):635-42.
PMID: 11448103
Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory...
10.
Stewart J, Wheatley D, Holmes J, MUIR I
Cell Biol Int
. 2001 Jul;
25(7):607-12.
PMID: 11448099
It was previously shown that a citric acid buffer extract of human dermis (extract D) inhibited growth of human diploid fibroblasts in monolayer culture (Muir et al., 1997). Further fractionation...