D Mochly-Rosen
Overview
Explore the profile of D Mochly-Rosen including associated specialties, affiliations and a list of published articles.
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88
Citations
3637
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Recent Articles
1.
Joshi A, Ebert A, Haileselassie B, Mochly-Rosen D
J Mol Cell Cardiol
. 2018 Dec;
127:125-133.
PMID: 30550751
Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in...
2.
Caino M, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz M
Oncogene
. 2011 Oct;
31(20):2593-600.
PMID: 21996750
Protein kinase C (PKC)ɛ, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKCɛ is frequently overexpressed in epithelial cancers,...
3.
Kim J, Thorne S, Sun L, Huang B, Mochly-Rosen D
Oncogene
. 2010 Sep;
30(3):323-33.
PMID: 20856202
Metastasis is the major reason for breast cancer-related deaths. Although there is a host of indirect evidence for a role of protein kinase C (PKC) α in primary breast cancer...
4.
Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine M
Transplant Proc
. 2008 Apr;
40(2):375-8.
PMID: 18374073
Strategies inhibiting cell death signaling pathways may enhance the availability of islet transplantation for patients with type 1 diabetes mellitus. The epsilon isoform of protein kinase C (PKC epsilon) has...
5.
Budas G, Mochly-Rosen D
Biochem Soc Trans
. 2007 Oct;
35(Pt 5):1052-4.
PMID: 17956277
Mitochondria mediate diverse cellular functions including energy generation and ROS (reactive oxygen species) production and contribute to signal transduction. Mitochondria are also key regulators of cell viability and play a...
6.
Churchill E, Mochly-Rosen D
Biochem Soc Trans
. 2007 Oct;
35(Pt 5):1040-2.
PMID: 17956273
Reperfusion of ischaemic cardiac tissue is associated with increased apoptosis and oncosis, resulting in diminished heart function. Short bouts of ischaemia before the prolonged ischaemic event (ischaemic preconditioning) protect the...
7.
Budas G, Koyanagi T, Churchill E, Mochly-Rosen D
Biochem Soc Trans
. 2007 Oct;
35(Pt 5):1021-6.
PMID: 17956268
PKC (protein kinase C) isoenzymes are related protein kinases, involved in many signalling events in normal state and in disease. Basic research into identifying the molecular basis of PKC selectivity...
8.
Inagaki K, Mochly-Rosen D
J Mol Cell Cardiol
. 2005 Jul;
39(2):203-11.
PMID: 15990110
Previous studies have demonstrated that acute ethanol exposure induces activation of delta protein kinase C (deltaPKC) and epsilonPKC, and mimics ischemic preconditioning via epsilonPKC activation. However, the role of deltaPKC...
9.
Chen L, WRIGHT L, Chen C, Oliver S, Wender P, Mochly-Rosen D
Chem Biol
. 2002 Jan;
8(12):1123-9.
PMID: 11755391
Background: Recently, we reported a novel oligoguanidine transporter system, polyarginine (R(7)), which, when conjugated to spectroscopic probes (e.g., fluorescein) and drugs (e.g., cyclosporin A), results in highly water-soluble conjugates that...
10.
Schechtman D, Mochly-Rosen D
Oncogene
. 2001 Oct;
20(44):6339-47.
PMID: 11607837
Spatial and temporal organization of signal transduction is essential in determining the speed and precision by which signaling events occur. Adaptor proteins are key to organizing signaling enzymes near their...