D M Wilson 3rd
Overview
Explore the profile of D M Wilson 3rd including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1601
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Recent Articles
1.
Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste B, Leandro G, et al.
Mol Cell Biol
. 2017 Jun;
37(16).
PMID: 28559431
We have detected DNA polymerase beta (Polβ), known as a key nuclear base excision repair (BER) protein, in mitochondrial protein extracts derived from mammalian tissue and cells. Manipulation of the...
2.
Karahalil B, Bohr V, Wilson 3rd D
Hum Exp Toxicol
. 2012 Oct;
31(10):981-1005.
PMID: 23023028
Genetic variation in DNA repair genes can modulate DNA repair capacity and may be related to cancer risk. However, study findings have been inconsistent. Inheritance of variant DNA repair genes...
3.
Illuzzi J, Wilson 3rd D
Curr Med Chem
. 2012 Jul;
19(23):3922-36.
PMID: 22788768
Cancer treatments often lose their effectiveness due to the development of multiple drug resistance. Thus, identification of key proteins involved in the tumorigenic process and the survival mechanism(s), coupled with...
4.
Mohammed M, Vyjayanti V, Laughton C, Dekker L, Fischer P, Wilson 3rd D, et al.
Br J Cancer
. 2011 Jan;
104(4):653-63.
PMID: 21266972
Aims: Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein...
5.
Wyatt M, Wilson 3rd D
Cell Mol Life Sci
. 2008 Nov;
66(5):788-99.
PMID: 18979208
The anti-metabolite 5-fluorouracil (5-FU) is employed clinically to manage solid tumors including colorectal and breast cancer. Intracellular metabolites of 5-FU can exert cytotoxic effects via inhibition of thymidylate synthetase, or...
6.
Lipton A, Heck R, Primak S, McNeill D, Wilson 3rd D, Ellis P
J Am Chem Soc
. 2008 Jun;
130(29):9332-41.
PMID: 18576638
Apurinic/apyrimidinic endonuclease 1 (APE1), a member of the divalent cation-dependent phosphoesterase superfamily of proteins that retain the conserved four-layered alpha/beta-sandwich structural core, is an essential protein that functions as part...
7.
Wilson 3rd D, McNeill D
Neuroscience
. 2006 Aug;
145(4):1187-200.
PMID: 16934943
Reactive oxygen species generated during normal cellular metabolism react with lipids, proteins, and nucleic acid. Evidence indicates that the accumulation of oxidative damage results in cellular dysfunction or deterioration. In...
8.
Schild L, Brookman K, Thompson L, Wilson 3rd D
Somat Cell Mol Genet
. 2004 Aug;
25(5-6):253-62.
PMID: 15328905
In vitro biochemical studies indicate that Ape1 is the major mammalian enzyme responsible for repairing abasic lesions in DNA and a significant factor in the processing of specific 3'-replication-blocking termini....
9.
Stuart J, Hashiguchi K, Wilson 3rd D, Copeland W, Souza-Pinto N, Bohr V
Nucleic Acids Res
. 2004 Apr;
32(7):2181-92.
PMID: 15107486
Mitochondrial DNA (mtDNA) contains higher steady-state levels of oxidative damage and mutates at rates significantly greater than nuclear DNA. Oxidative lesions in mtDNA are removed by a base excision repair...
10.
Wilson 3rd D, BARSKY D
Mutat Res
. 2001 Oct;
485(4):283-307.
PMID: 11585362
DNA continuously suffers the loss of its constituent bases, and thereby, a loss of potentially vital genetic information. Sites of missing bases--termed abasic or apurinic/apyrimidinic (AP) sites--form spontaneously, through damage-induced...