D M Virshup
Overview
Explore the profile of D M Virshup including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
2463
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Recent Articles
1.
Zhang F, Virshup D, Cheong J
Oncogene
. 2017 Sep;
37(3):363-376.
PMID: 28945225
Evasion of forkhead box O (FOXO) family of longevity-related transcription factors-mediated growth suppression is necessary to promote cancer development. Since somatic alterations or mutations and transcriptional dysregulation of the FOXO...
2.
Somarelli J, Schaeffer D, Marengo M, Bepler T, Rouse D, Ware K, et al.
Oncogene
. 2016 Jan;
35(33):4302-11.
PMID: 26751776
The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support for the role...
3.
Madan B, Ke Z, Harmston N, Ho S, Frois A, Alam J, et al.
Oncogene
. 2015 Aug;
35(17):2197-207.
PMID: 26257057
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical...
4.
Yim D, Ghosh S, Guy G, Virshup D
Oncogene
. 2014 Jan;
34(4):474-84.
PMID: 24469046
Sprouty2 (SPRY2) is a potent negative regulator of receptor tyrosine kinase signaling, and is implicated as a tumor suppressor. SPRY2 inhibits FGF-RAS-ERK signaling by binding to growth factor receptor bound...
5.
Coombs G, Schmitt A, Canning C, Alok A, Low I, Banerjee N, et al.
Oncogene
. 2011 Jun;
31(2):213-25.
PMID: 21666721
Using a screen for Wnt/β-catenin inhibitors, a family of 8-hydroxyquinolone derivatives with in vivo anti-cancer properties was identified. Analysis of microarray data for the lead compound N-((8-hydroxy-7-quinolinyl) (4-methylphenyl)methyl)benzamide (HQBA) using...
6.
Cheong J, Nguyen T, Wang H, Tan P, Voorhoeve P, Lee S, et al.
Oncogene
. 2011 Jan;
30(22):2558-69.
PMID: 21258417
Casein kinase 1 delta and epsilon (CK1δ/ɛ) are key regulators of diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. Recent studies suggest that they...
7.
Virshup D, Eide E, Forger D, Gallego M, Harnish E
Cold Spring Harb Symp Quant Biol
. 2008 Apr;
72:413-20.
PMID: 18419299
Protein phosphorylation regulates the period of the circadian clock within mammalian cells. Circadian rhythms are an approximately 24-hour cycle that regulates key biological processes. Daily fluctuations of wakefulness, stress hormones,...
8.
Vielhaber E, Duricka D, Ullman K, Virshup D
J Biol Chem
. 2001 Oct;
276(49):45921-7.
PMID: 11591712
The timing of mammalian circadian rhythm is determined by interlocking negative and positive transcriptional feedback loops that govern the cyclic expression of both clock regulators and output genes. In mammals,...
9.
Li X, Yost H, Virshup D, Seeling J
EMBO J
. 2001 Aug;
20(15):4122-31.
PMID: 11483515
Wnt signaling increases beta-catenin abundance and transcription of Wnt-responsive genes. Our previous work suggested that the B56 regulatory subunit of protein phosphatase 2A (PP2A) inhibits Wnt signaling. Okadaic acid (a...
10.
Eide E, Virshup D
Chronobiol Int
. 2001 Jul;
18(3):389-98.
PMID: 11475410
Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates...