D M Gamm

Overview

Explore the profile of D M Gamm including associated specialties, affiliations and a list of published articles.

Snapshot

Articles 8

Citations 168

Followers 0

Related Specialties

Biochemistry

Ophthalmology

Science

Top 10 Co-Authors

M D Uhler

S P Collins

A F Seasholtz

S H Francis

M A Scarpetta

J D Corbin

A T Thliveris

A A DePaoli-Roach

J L Reoma

L K Barthel

Published In

J Biol Chem

Invest Ophthalmol Vis Sci

Proc Natl Acad Sci U S A

Arch Ophthalmol

Biochem J

Affiliations

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Recent Articles

Implications of genetic analysis in Leber congenital amaurosis

Gamm D, Thliveris A

Arch Ophthalmol . 2001 Mar; 119(3):426-7. PMID: 11231777

No abstract available.

Localization of cGMP-dependent protein kinase isoforms in mouse eye

Gamm D, Barthel L, Raymond P, Uhler M

Invest Ophthalmol Vis Sci . 2000 Aug; 41(9):2766-73. PMID: 10937596

Purpose: To examine the expression of the major isoforms of cyclic guanosine monophosphate (cGMP)-dependent protein kinase (cGK) in mouse eye. Methods: Immunohistochemical localization of cGMP in mouse eye cryosections was...

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

Collins S, Reoma J, Gamm D, Uhler M

Biochem J . 2000 Jan; 345 Pt 3:673-80. PMID: 10642527

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease characterized by melanocytic macules, hamartomatous polyps and an increased risk for numerous cancers. The human LKB1 (hLKB1) gene encodes a serine/threonine protein...

Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase

Hall K, Collins S, Gamm D, Massa E, DePaoli-Roach A, Uhler M

J Biol Chem . 1999 Jan; 274(6):3485-95. PMID: 9920894

G-substrate, a specific substrate of the cGMP-dependent protein kinase, has previously been localized to the Purkinje cells of the cerebellum. We report here the isolation from mouse brain of a...

The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo

Gamm D, Baude E, Uhler M

J Biol Chem . 1996 Jun; 271(26):15736-42. PMID: 8662989

Two isoforms of the catalytic subunit of cAMP-dependent protein kinase, Calpha and Cbeta1, are known to be widely expressed in mammals. Although much is known about the structure and function...

The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms

Gamm D, Francis S, Angelotti T, Corbin J, Uhler M

J Biol Chem . 1995 Nov; 270(45):27380-8. PMID: 7593002

The type I cGMP-dependent protein kinases (cGK I alpha and I beta) form homodimers (subunit M(r) approximately 76,000), presumably through conserved, amino-terminal leucine zipper motifs. Type II cGMP-dependent protein kinase...

Isoform-specific differences in the potencies of murine protein kinase inhibitors are due to nonconserved amino-terminal residues

Gamm D, Uhler M

J Biol Chem . 1995 Mar; 270(13):7227-32. PMID: 7706262

We provide here a detailed characterization of two isoforms of the protein kinase inhibitor (PKI) protein of cAMP-dependent protein kinase that have dramatically different inhibition constants. Murine PKI beta 1...

Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain

Seasholtz A, Gamm D, Ballestero R, Scarpetta M, Uhler M

Proc Natl Acad Sci U S A . 1995 Feb; 92(5):1734-8. PMID: 7878050

Many neurotransmitters are known to regulate neuronal cell function by means of activation of cAMP-dependent protein kinase (PKA) and phosphorylation of neuronal substrate proteins, including transcription factors and ion channels....