D Le Roith
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Explore the profile of D Le Roith including associated specialties, affiliations and a list of published articles.
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60
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1346
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Recent Articles
1.
Bloomgarden Z, Inzucchi S, Karnieli E, Le Roith D
Diabetologia
. 2008 May;
51(7):1111-4.
PMID: 18449525
The proposed use of a more precise standard for glycated (A(1c)) and non-glycated haemoglobin would lead to an A(1c) value, when expressed as a percentage, that is lower than that...
2.
Le Roith D
Clin Cornerstone
. 2002 Feb;
4(2):38-49.
PMID: 11838326
Although type 2 diabetes is a heterogeneous disorder, there are certain management goals that are common to all patients. Tight metabolic control reduces the complication rates; therefore, for patients with...
3.
Pietropaolo M, Le Roith D
Clin Cornerstone
. 2002 Feb;
4(2):1-16.
PMID: 11838323
Understanding the pathogenesis of any disease is of prime importance when considering treatment. Recent breakthroughs in the evaluation and management of diabetes and the availability of new therapeutic regimens make...
4.
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
Fernandez A, Kim J, Yakar S, Dupont J, Hernandez-Sanchez C, Castle A, et al.
Genes Dev
. 2001 Aug;
15(15):1926-34.
PMID: 11485987
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose disposal in...
5.
Dupont J, Le Roith D
Mol Pathol
. 2001 May;
54(3):149-54.
PMID: 11376126
In MCF-7 breast cancer cells, the insulin-like growth factor 1 receptor (IGF-1R) and the oestrogen receptor (ER) are coexpressed and the two signalling systems are engaged in a crosstalk that...
6.
Le Roith D, Karas M, Yakar S, Qu B, Wu Y, Blakesley V
Isr Med Assoc J
. 2001 May;
1(1):25-30.
PMID: 11370118
No abstract available.
7.
Yakar S, Liu J, Fernandez A, Wu Y, Schally A, Frystyk J, et al.
Diabetes
. 2001 May;
50(5):1110-8.
PMID: 11334415
Insulin and insulin-like growth factors (IGFs) mediate a variety of signals involved in mammalian development and metabolism. To study the metabolic consequences of IGF-I deficiency, we used the liver IGF-I-deficient...
8.
9.
Butler A, Le Roith D
Annu Rev Physiol
. 2001 Feb;
63:141-64.
PMID: 11181952
The traditionally accepted theory has been that most of the biological effects of growth hormone (GH) are mediated by circulating (endocrine) insulin-like growth factor-I (IGF-I). This dogma was modified when...
10.
Deb D, Lanyi A, Scian M, Keiger J, Brown D, Le Roith D, et al.
Int J Oncol
. 2001 Feb;
18(2):401-9.
PMID: 11172610
p73 has been shown to transcriptionally activate genes positively responsive to wild-type p53. In order to undertake a comparative study of functions of p53 and p73 we have cloned the...