D Larry Sparks
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Explore the profile of D Larry Sparks including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
1783
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Recent Articles
1.
Schreurs B, Sparks D
J Alzheimers Dis
. 2015 Oct;
49(1):201-9.
PMID: 26444796
Background: Cholesterol-fed rabbits have been documented to show increased amyloid-β (Aβ) deposits in the brain that can be exacerbated by the quality of drinking water especially if rabbits drink tap...
2.
Sparks D, Kryscio R, Sabbagh M, Ziolkowski C, Lin Y, Sparks L, et al.
Am J Neurodegener Dis
. 2013 Feb;
1(1):99-106.
PMID: 23383382
Objective: Measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and...
3.
Sabbagh M, Malek-Ahmadi M, Levenson I, Sparks D
J Alzheimers Dis
. 2012 Aug;
33(1):111-6.
PMID: 22914592
KIF6 719Arg allele carriers are thought to have a greater lipid lowering response from statin therapy than non-carriers. Given the continued interest in the relationship between cholesterol, statin use, amnestic...
4.
Sabbagh M, Sparks D
Expert Rev Neurother
. 2012 Jan;
12(1):27-30.
PMID: 22243043
The link between cholesterol and Alzheimer's disease (AD) has been explored for almost two decades. The link stems from the observation that atherosclerotic heart disease increases the risk for AD...
5.
Deci S, Lemieux S, Smith-Bell C, Sparks D, Schreurs B
J Alzheimers Dis
. 2012 Jan;
29(2):283-92.
PMID: 22232012
One of the hallmarks of Alzheimer's disease is a significant increase in ventricular volume. To date we and others have shown that a cholesterol-fed rabbit model of Alzheimer's disease displays...
6.
Squitti R, Sparks D, Hoogenraad T, Brewer G
Int J Alzheimers Dis
. 2012 Jan;
2011:903940.
PMID: 22216415
No abstract available.
7.
8.
Sparks D, Ziolkowski C, Lawmaster T, Martin T
Int J Alzheimers Dis
. 2011 May;
2011:987023.
PMID: 21559186
The studies employed the cholesterol-fed rabbit model of Alzheimer's disease (AD) to investigate the relationship between AD-like neurofibrillary tangle (NFT) neuropathology and tau protein levels as the main component of...
9.
Lemieux S, Smith-Bell C, Wells J, Ezerioha N, Carpenter J, Sparks D, et al.
J Magn Reson Imaging
. 2010 Aug;
32(2):306-14.
PMID: 20677255
Purpose: To test the hypothesis that narrowing of cranial blood vessels in cholesterol-fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by...
10.
Sparks D, Kryscio R, Connor D, Sabbagh M, Sparks L, Lin Y, et al.
Neurodegener Dis
. 2010 Mar;
7(1-3):183-6.
PMID: 20224282
Background: We reported a significant 67% reduction in the hazard risk of incident Alzheimer's disease (AD) with elective statin use in the AD Anti-inflammatory Prevention Trial (ADAPT), without a reduction...