Alzheimer Disease: Statins in the Treatment of Alzheimer Disease

Overview

Journal Nat Rev Neurol

Specialty Neurology

Date 2011 Oct 20

PMID 22009281

Citations 9

Authors

D Larry Sparks

Affiliations

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Citing Articles

Therapy for Alzheimer's disease: Missing targets and functional markers?.

Stoiljkovic M, Horvath T, Hajos M Ageing Res Rev. 2021; 68:101318.

PMID: 33711510 PMC: 8131215. DOI: 10.1016/j.arr.2021.101318.

Identifying biomarkers of dementia prevalent among amnestic mild cognitively impaired ethnic female patients.

Grewal R, Haghighi M, Huang S, Smith A, Cao C, Lin X Alzheimers Res Ther. 2016; 8(1):43.

PMID: 27756387 PMC: 5067885. DOI: 10.1186/s13195-016-0211-0.

Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier.

Griffin J, Kho D, Graham E, Nicholson L, OCarroll S PLoS One. 2016; 11(6):e0157483.

PMID: 27309956 PMC: 4911157. DOI: 10.1371/journal.pone.0157483.

Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1α genes in neural stem cells treated with hydrogen peroxide.

Abdanipour A, Tiraihi T, Noori-Zadeh A, Majdi A, Gosaili R Mol Neurobiol. 2014; 49(3):1364-72.

PMID: 24390568 DOI: 10.1007/s12035-013-8613-5.

Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets.

Barone E, Di Domenico F, Butterfield D Biochem Pharmacol. 2013; 88(4):605-16.

PMID: 24231510 PMC: 3972306. DOI: 10.1016/j.bcp.2013.10.030.

References

Sparks D, Sabbagh M, Connor D, Lopez J, Launer L, Browne P . Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol. 2005; 62(5):753-7. DOI: 10.1001/archneur.62.5.753. View

Sano M, Bell K, Galasko D, Galvin J, Thomas R, van Dyck C . A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology. 2011; 77(6):556-63. PMC: 3149154. DOI: 10.1212/WNL.0b013e318228bf11. View

Sparks D, Kryscio R, Sabbagh M, Connor D, Sparks L, Liebsack C . Reduced risk of incident AD with elective statin use in a clinical trial cohort. Curr Alzheimer Res. 2008; 5(4):416-21. DOI: 10.2174/156720508785132316. View

Sparks D, Kryscio R, Connor D, Sabbagh M, Sparks L, Lin Y . Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort. Neurodegener Dis. 2010; 7(1-3):183-6. PMC: 2859238. DOI: 10.1159/000295660. View

Feldman H, Doody R, Kivipelto M, Sparks D, Waters D, Jones R . Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology. 2010; 74(12):956-64. DOI: 10.1212/WNL.0b013e3181d6476a. View