D Langosch
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Explore the profile of D Langosch including associated specialties, affiliations and a list of published articles.
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41
Citations
1546
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Recent Articles
1.
Langosch D, Scharnagl C, Steiner H, Lemberg M
Trends Biochem Sci
. 2015 May;
40(6):318-27.
PMID: 25941170
Intramembrane proteolysis - cleavage of proteins within the plane of a membrane - is a widespread phenomenon that can contribute to the functional activation of substrates and is involved in...
2.
Ollesch J, Poschner B, Nikolaus J, Hofmann M, Herrmann A, Gerwert K, et al.
Eur Biophys J
. 2007 Nov;
37(4):435-45.
PMID: 18038229
LV-peptides were designed as membrane-spanning low-complexity model structures that mimic fusion protein transmembrane domains. These peptides harbor a hydrophobic core sequence that consists of helix-promoting and helix-destabilizing residues at different...
3.
Langosch D, Hofmann M, Ungermann C
Cell Mol Life Sci
. 2007 Apr;
64(7-8):850-64.
PMID: 17429580
Biological membrane fusion is driven by different types of molecular fusion machines. Most of these proteins are membrane-anchored by single transmembrane domains. SNARE proteins are essential for intracellular membrane fusion...
4.
Roy R, Peplowska K, Rohde J, Ungermann C, Langosch D
Biochemistry
. 2006 Jun;
45(24):7654-60.
PMID: 16768461
Intracellular membrane fusion in eukaryotic cells is mediated by SNARE (soluble N-ethylmaleimide sensitive factor (NSF) attachment protein receptor) proteins and is known to involve assembly of cognate subunits to heterooligomeric...
5.
Gurezka R, Langosch D
J Biol Chem
. 2001 Oct;
276(49):45580-7.
PMID: 11585820
A membrane-spanning heptad repeat motif mediates interaction between transmembrane segments. This motif was randomized with three different sets of mostly hydrophobic residues in the context of POSSYCCAT, a modified ToxR...
6.
Langosch D, Crane J, Brosig B, Hellwig A, Tamm L, Reed J
J Mol Biol
. 2001 Aug;
311(4):709-21.
PMID: 11518525
SNARE proteins are essential for different types of intracellular membrane fusion. Whereas interaction between their cytoplasmic domains is held responsible for establishing membrane proximity, the role of the transmembrane segments...
7.
Langosch D, Brosig B, Pipkorn R
J Biol Chem
. 2001 Jun;
276(34):32016-21.
PMID: 11418597
The efficiency of cell-cell fusion mediated by heterologously expressed vesicular stomatitis virus G-protein has previously been shown to be affected by mutating its transmembrane segment. Here, we show that a...
8.
Laage R, Langosch D
Traffic
. 2001 Mar;
2(2):99-104.
PMID: 11247308
High-level heterologous expression of integral membrane proteins at full-length is a useful tool for their structural and functional characterization. Here, systems that have previously been used for efficient bacterial expression...
9.
Kubatzky K, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich S, et al.
Curr Biol
. 2001 Mar;
11(2):110-5.
PMID: 11231127
Hematopoietic cytokine receptors, such as the erythropoietin receptor (EpoR), are single membrane-spanning proteins. Signal transduction through EpoR is crucial for the formation of mature erythrocytes. Structural evidence shows that in...
10.
Laage R, Rohde J, Brosig B, Langosch D
J Biol Chem
. 2000 Apr;
275(23):17481-7.
PMID: 10764817
Assembly of the SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 to binary and ternary complexes is important for docking and/or fusion of presynaptic vesicles to the neuronal plasma membrane prior to...