D L Williams Jr
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Explore the profile of D L Williams Jr including associated specialties, affiliations and a list of published articles.
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24
Citations
881
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Recent Articles
1.
Liu Q, Guan X, Martin W, McDONALD T, Clements M, Jiang Q, et al.
J Biol Chem
. 2001 Aug;
276(40):36961-9.
PMID: 11481330
The two mammalian neuropeptides NPFF and NPAF have been shown to have important roles in nociception, anxiety, learning and memory, and cardiovascular reflex. Two receptors (FF1 and FF2) have been...
2.
Howard A, Wang R, Pong S, Mellin T, Strack A, Guan X, et al.
Nature
. 2000 Jul;
406(6791):70-4.
PMID: 10894543
Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species. It is widely distributed in...
3.
Heise C, ODowd B, Figueroa D, Sawyer N, Nguyen T, Im D, et al.
J Biol Chem
. 2000 Jun;
275(39):30531-6.
PMID: 10851239
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC(4), LTD(4), and LTE(4), are thought to be mediated through at least two distinct but related CysLT G protein-coupled receptors....
4.
Liu Q, Pong S, Zeng Z, Zhang Q, Howard A, Williams Jr D, et al.
Biochem Biophys Res Commun
. 1999 Dec;
266(1):174-8.
PMID: 10581185
Urotensin II (UII) is a neuropeptide with potent cardiovascular effects. Its sequence is strongly conserved among different species and has structural similarity to somatostatin. No receptor for UII has been...
5.
Krause S, Nolan N, Clayton F, Walsh T, Williams Jr D
J Cardiovasc Pharmacol
. 1999 Sep;
34(3):359-67.
PMID: 10470993
The pharmacology of endothelin (ET)-1, big ET-1, ET-3, and S6c were characterized in the anesthetized ferret to assess whether this species would provide a new and suitable nonrodent model to...
6.
Lynch K, ONeill G, Liu Q, Im D, Sawyer N, Metters K, et al.
Nature
. 1999 Jul;
399(6738):789-93.
PMID: 10391245
The cysteinyl leukotrienes-leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE4)-are important mediators of human bronchial asthma. Pharmacological studies have determined that cysteinyl leukotrienes activate at least two receptors, designated CysLT1 and...
7.
Suzuki M, Ohte N, Wang Z, Williams Jr D, Little W, Cheng C
Cardiovasc Res
. 1998 Dec;
39(3):589-99.
PMID: 9861301
Objective: The positive inotropic effect of endothelin-1 (ET-1) on normal myocardial contraction may be altered in pathological states. The purpose of this study was to assess the direct effect of...
8.
Krause S, Walsh T, Greenlee W, Ranaei R, Williams Jr D, Kivlighn S
J Am Soc Nephrol
. 1997 Jul;
8(7):1061-71.
PMID: 9219155
Renal insufficiency is a significant complication that occurs after surgical procedures, requiring cross-clamping of the aorta. The mechanism for this renal dysfunction is currently not known, but studies suggest a...
9.
Williams Jr D, Murphy K, Nolan N, OBrien J, Lis Jr E, Pettibone D, et al.
Life Sci
. 1996 Jan;
58(14):1149-57.
PMID: 8614266
L-744,453 ((+/-)3-[4-(1-carboxy-1-(3,4-methylenedioxyphenyl)methoxy)-3,5-diprop ylphenyl methyl]-3H-imidazo[4,5-c]pyridine) is an endothelin (ET) receptor antagonist from a new structural class, the dipropyl-alpha-phenoxyphenylacetic acid derivatives. L-744,453 competitively and reversibly inhibits [125I]-ET-1 binding to Chinese Hamster Ovary...
10.
Williams Jr D, Murphy K, Nolan N, OBrien J, Pettibone D, Kivlighn S, et al.
J Pharmacol Exp Ther
. 1995 Dec;
275(3):1518-26.
PMID: 8531124
L-754,142, (-)-N-(4-iso-propylbenzenesulfonyl)-alpha-(4-carboxyl-2-n-propy lphenoxy)-3,4- methylenedioxyphenylacetamide, is a potent nonpeptidyl endothelin antagonist (e.g., Ki: cloned human ETA = 0.062 nM: cloned human ETB = 2.25 nM), with high specificity for endothelin receptors....