D L Tait
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Explore the profile of D L Tait including associated specialties, affiliations and a list of published articles.
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10
Citations
43
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Recent Articles
1.
Tait D, Jensen R, Holt J, Johnson D, Gralow J, King M
Breast Dis
. 2005 Feb;
10(1-2):89-98.
PMID: 15687552
As an initial step toward gene therapy for ovarian cancer, we conducted a Phase 1 trial to assess the pharmacokinetics and toxicity of intraperitoneal BRCA1sv retroviral vector therapy. Gene transfer...
2.
Obermiller P, Tait D, Holt J
Breast Cancer Res
. 2001 Mar;
2(1):28-31.
PMID: 11250690
Gene therapy is a therapeutic approach that is designed to correct specific molecular defects that contribute to the cause or progression of cancer. Genes that are mutated or deleted in...
3.
Tait D, Obermiller P, Holt J
Gynecol Oncol
. 2000 Dec;
79(3):471-6.
PMID: 11104622
Objective: The aim of this study was to determine the preclinical stability, toxicity, and efficacy of a second-generation complement-resistant retroviral BRCA1 vector, MFG-BRCA1, for ovarian cancer gene therapy. Methods: MFG-BRCA1...
4.
Tait D, Obermiller P, Hatmaker A, Holt J
Clin Cancer Res
. 1999 Aug;
5(7):1708-14.
PMID: 10430073
Gene therapy with viral vectors has shown some promise in nude mice models and in initial Phase I trials of patients with extensive metastatic cancer. A Phase I clinical trial...
5.
Tait D, Obermiller P, Jensen R, Welcsh P, Dann J, King M, et al.
Clin Cancer Res
. 1998 Nov;
3(11):1959-68.
PMID: 9815585
Gene transfer of BRCA1sv (a normal splice variant of BRCA1) into ovarian cancer cells produces growth inhibition in vitro and tumor suppression in nude mouse xenografts. As an initial step...
6.
Tait D, Obermiller P, Jensen R, Holt J
Hematol Oncol Clin North Am
. 1998 Jul;
12(3):539-52.
PMID: 9684097
Retroviral-mediated delivery of BRCA1 gene therapy (LXN-BRCA1sv, a normal splice variant form of BRCA1) was tested extensively in mouse models. It was found to be effective in reducing tumor burden...
7.
Tait D, Williams J, Sandstad J, Lucci 3rd J
Am J Perinatol
. 1997 Oct;
14(8):461-4.
PMID: 9376006
Cystic lesions of the adrenal gland are uncommon, most often diagnosed incidentally during diagnostic imaging or autopsy. An adrenal cyst presenting as a pelvic mass in pregnancy offers the clinician...
8.
Tait D, Miller D
Tex Med
. 1997 Jan;
93(1):89-91.
PMID: 9210846
A woman's lifetime risk of developing an ovarian neoplasm is approximately 7%. A small subset of these neoplasms comprises the gigantic ovarian tumors (> 25 lbs) that often present challenging...
9.
Tait D, MACDONALD P, CASEY M
Cancer
. 1994 Mar;
73(5):1515-21.
PMID: 8111720
Background: The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous...
10.
Waddell T, Gebert P, Tait D
J Pharm Sci
. 1983 Dec;
72(12):1474-6.
PMID: 6663489
The antitumor pseudoguaianolide tenulin has been exposed to a wide variety of biological and model nucleophilic reagents and has been shown to react exclusively with sulfur nucleophiles in a Michael-like...