D G Wynne
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Explore the profile of D G Wynne including associated specialties, affiliations and a list of published articles.
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11
Citations
78
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Recent Articles
1.
Wynne D, Del Monte F, Harding S
Eur J Pharmacol
. 1996 Aug;
310(2-3):235-42.
PMID: 8884222
Chronic activation of the sympathetic nervous system in human heart failure is believed to cause cardiac beta-adrenoceptor desensitisation. We have investigated the relationship between beta-adrenoceptor desensitisation and cyclic AMP levels...
2.
McMahon A, Vescovo G, Dalla Libera L, Wynne D, Fluck R, Harding S, et al.
Exp Nephrol
. 1996 May;
4(3):144-50.
PMID: 8773476
In order to clarify the mechanism underlying impaired cardiac performance in uraemia, the contractile function of isolated cardiac myocytes from chronically uraemic and control rats has been compared. Rats were...
3.
Martin X, Wynne D, Glennon P, Moorman A, Boheler K
Mol Cell Biochem
. 1996 Apr;
157(1-2):181-9.
PMID: 8739245
Transitions in sarcomeric alpha-actin and cardiac myosin heavy chain (MHC) gene expression have been useful as molecular markers for the development of cardiac hypertrophy and failure. In simpler model systems,...
4.
Harding S, Brown L, Del Monte F, Davies C, OGara P, Vescovo G, et al.
Basic Res Cardiol
. 1996 Jan;
91 Suppl 2:53-6.
PMID: 8957545
Myocytes from failing human ventricle contract and relax more slowly than those from non-failing. This has been suggested to result from the lowering of basal cyclic AMP level in failing...
5.
Petrou M, Wynne D, Boheler K, Yacoub M
Circulation
. 1995 Nov;
92(9 Suppl):II483-9.
PMID: 7586459
Background: Skeletal muscle assistance of the circulation for patients in end-stage heart failure requires electrical training of the latissimus dorsi flap to produce fatigue resistance. This process of electrical transformation...
6.
Harding S, MacLeod K, Davies C, Wynne D, Poole-Wilson P
Eur Heart J
. 1995 Aug;
16 Suppl I:74-81.
PMID: 8829961
Acute myocardial ischemia and subsequent reperfusion result in biochemical and ionic changes in cardiac myocytes which cause contracture of the muscle and a reduced contractile force. Whether changes observed in...
7.
Decreased contractile responses to isoproterenol in isolated cardiac myocytes from aging guinea-pigs
Ferrara N, OGara P, Wynne D, Brown L, Del Monte F, Poole-Wilson P, et al.
J Mol Cell Cardiol
. 1995 May;
27(5):1141-50.
PMID: 7473772
We have characterized the age-related changes of contractility and beta-adrenoceptor function in isolated cardiac myocytes from guinea-pigs. We used either adult animals from 2 to 14 weeks of age, where...
8.
Harding S, Davies C, Wynne D, Poole-Wilson P
Eur Heart J
. 1994 Dec;
15 Suppl D:35-6.
PMID: 7713111
Ventricular myocytes from failing human hearts have a similar maximum contraction amplitude in high Ca2+ to those from non-failing heart at low stimulation rates (0.2 Hz, 32 degrees C), but...
9.
Harding S, Brown L, Wynne D, Davies C, Poole-Wilson P
Cardiovasc Res
. 1994 Oct;
28(10):1451-60.
PMID: 8001031
No abstract available.
10.
Del Monte F, Kaumann A, Poole-Wilson P, Wynne D, Pepper J, Harding S
Circulation
. 1993 Sep;
88(3):854-63.
PMID: 8102599
Background: Both beta 1- and beta 2-adrenoceptors (beta 1 AR and beta 2 AR) are present in human ventricle. This study was designed to determine whether the two subtypes contribute...