D Ethier
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Explore the profile of D Ethier including associated specialties, affiliations and a list of published articles.
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28
Citations
497
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Recent Articles
1.
Riendeau D, Percival M, Brideau C, Charleson S, Dube D, Ethier D, et al.
J Pharmacol Exp Ther
. 2001 Feb;
296(2):558-66.
PMID: 11160644
We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) pyridine], a novel orally active agent that selectively inhibits cyclooxygenase-2 (COX-2), that has been developed for high selectivity in vitro...
2.
Lau C, Brideau C, Chan C, Charleson S, Cromlish W, Ethier D, et al.
Bioorg Med Chem Lett
. 1999 Nov;
9(22):3187-92.
PMID: 10576685
A series of 3-heteroaryloxy4-phenyl-2-5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective...
3.
Frenette R, Hutchinson J, Leger S, THERIEN M, Brideau C, Chan C, et al.
Bioorg Med Chem Lett
. 1999 Sep;
9(16):2391-6.
PMID: 10476875
This paper reports on the SAR investigation of inhibitors of 5-lipoxygenase activating protein (FLAP) based on MK-0591. Emphasis was made on modifications to the nature of the link between the...
4.
Cuncic C, Detich N, Ethier D, Tracey A, Gresser M, Ramachandran C
J Biol Inorg Chem
. 1999 Aug;
4(3):354-9.
PMID: 10439081
Vanadate is a potent reversible inhibitor of protein tyrosine phosphatases (PTP) in vitro. Vanadate has been shown to increase the phosphotyrosine levels in some cell types whereas in others, like...
5.
Chan C, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, et al.
J Pharmacol Exp Ther
. 1999 Jul;
290(2):551-60.
PMID: 10411562
The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in the...
6.
Prasit P, Wang Z, Brideau C, Chan C, Charleson S, Cromlish W, et al.
Bioorg Med Chem Lett
. 1999 Jul;
9(13):1773-8.
PMID: 10406640
The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described. It is essentially equipotent to indomethacin both in vitro and in vivo but without the ulcerogenic side effect...
7.
Black W, Brideau C, Chan C, Charleson S, Chauret N, Claveau D, et al.
J Med Chem
. 1999 Apr;
42(7):1274-81.
PMID: 10197970
Cyclopentenones containing a 4-(methylsulfonyl)phenyl group in the 3-position and a phenyl ring in the 2-position are selective inhibitors of cyclooxygenase-2 (COX-2). The selectivity for COX-2 over COX-1 is dramatically improved...
8.
Friesen R, Brideau C, Chan C, Charleson S, Deschenes D, Dube D, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(19):2777-82.
PMID: 9873621
A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2. Optimum COX-2 activity is observed by...
9.
Dube D, Blouin M, Brideau C, Chan C, Desmarais S, Ethier D, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(10):1255-60.
PMID: 9871745
Leukotriene biosynthesis inhibitors have potential as new therapeutic agents for asthma and inflammatory diseases. A series of novel substituted 2-cyanoquinolines have been synthesized and the structure activity relationships were evaluated...
10.
Hamel P, Riendeau D, Brideau C, Chan C, Desmarais S, Delorme D, et al.
J Med Chem
. 1997 Aug;
40(18):2866-75.
PMID: 9288168
Dioxabicyclooctanyl naphthalenenitriles have been reported as a class of potent and nonredox 5-lipoxygenase (5-LO) inhibitors. These bicyclo derivatives were shown to be metabolically more stable than their tetrahydropyranyl counterparts but...