D E Levy
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Explore the profile of D E Levy including associated specialties, affiliations and a list of published articles.
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130
Citations
6453
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Recent Articles
11.
Levy D, Garcia-Sastre A
Cytokine Growth Factor Rev
. 2001 Apr;
12(2-3):143-56.
PMID: 11325598
Response to IFN involves a rapid and direct signal transduction mechanism that quickly reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity inherent in cytokine-receptor interactions...
12.
Kovarik P, Mangold M, Ramsauer K, Heidari H, Steinborn R, Zotter A, et al.
EMBO J
. 2001 Feb;
20(1-2):91-100.
PMID: 11226159
Complete activation of signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Y701 and a conserved PMS(727)P sequence. S727 phosphorylation of STAT1 in interferon-gamma (IFN-gamma)-treated mouse fibroblasts...
13.
Durbin J, Fernandez-Sesma A, Lee C, Rao T, Frey A, Moran T, et al.
J Immunol
. 2001 Feb;
164(8):4220-8.
PMID: 10754318
IFNs protect from virus infection by inducing an antiviral state and by modulating the immune response. Using mice deficient in multiple aspects of IFN signaling, we found that type I...
14.
Smith E, Marie I, Prakash A, Garcia-Sastre A, Levy D
J Biol Chem
. 2001 Jan;
276(12):8951-7.
PMID: 11124948
Induction of interferon-alpha (IFNalpha) gene expression in virus-infected cells requires phosphorylation-induced activation of the transcription factors IRF3 and IRF7. However, the kinase(s) that targets these proteins has not been identified....
15.
Marie I, Smith E, Prakash A, Levy D
Mol Cell Biol
. 2000 Nov;
20(23):8803-14.
PMID: 11073981
Interferon regulatory factor 7 (IRF7) is an interferon (IFN)-inducible transcription factor required for activation of a subset of IFN-alpha genes that are expressed with delayed kinetics following viral infection. IRF7...
16.
Lee C, Rao D, Gertner R, Gimeno R, Frey A, Levy D
J Immunol
. 2000 Oct;
165(7):3571-7.
PMID: 11034357
NK cell functions were examined in mice with a targeted mutation of the STAT1 gene, an essential mediator of IFN signaling. Mice deficient in STAT1 displayed impaired basal NK cytolytic...
17.
Schwaller J, Parganas E, Wang D, Cain D, Aster J, Williams I, et al.
Mol Cell
. 2000 Oct;
6(3):693-704.
PMID: 11030348
STAT5 is activated in a broad spectrum of human hematologic malignancies. We addressed whether STAT5 activation is necessary for the myelo- and lymphoproliferative disease induced by TEL/JAK2 using a genetic...
18.
Weiden M, Tanaka N, Qiao Y, Zhao B, Honda Y, Nakata K, et al.
J Immunol
. 2000 Aug;
165(4):2028-39.
PMID: 10925286
HIV-1 replication is inhibited in uninflamed lung macrophages and is stimulated during tuberculosis. Attempts to recapitulate activation of HIV-1 replication in primary monocytes and macrophages ex vivo and in the...
19.
Levy D, Gilliland D
Oncogene
. 2000 Jun;
19(21):2505-10.
PMID: 10851049
Stat proteins are latent transcription factors activated by tyrosine phosphorylation downstream of cytokine and growth factor receptors and have been implicated in a variety of cell growth regulatory pathways. Constitutive...
20.
Sherman D, ATKINSON R, Chippendale T, Levin K, Ng K, Futrell N, et al.
JAMA
. 2000 May;
283(18):2395-403.
PMID: 10815082
Context: Approved treatment options for acute ischemic stroke in the United States and Canada are limited at present to intravenous tissue-type plasminogen activator, but bleeding complications, including intracranial hemorrhage, are...