D De Stefanis
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Explore the profile of D De Stefanis including associated specialties, affiliations and a list of published articles.
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12
Citations
81
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Recent Articles
1.
Minero V, De Stefanis D, Costelli P, Baccino F, Bonelli G
Cell Cycle
. 2015 Jan;
14(7):1090-102.
PMID: 25564714
High mortality among hepatocellular carcinoma (HCC) patients reflects both late diagnosis and low curability, due to pharmacoresistance. Taxol (TAX) is toxic for many human HCC-derived cell lines, yet its clinical...
2.
Autelli R, Crepaldi S, De Stefanis D, Parola M, Bonelli G, Baccino F
Apoptosis
. 2005 Sep;
10(4):777-86.
PMID: 16133868
Rat hepatoma HTC cells are intrinsically resistant to various apoptosis-inducing agents. Strategies to induce death in hepatoma cells are needed and the present experimental study was aimed to investigate the...
3.
Isidoro C, De Stefanis D, Demoz M, Ogier-Denis E, Codogno P, Baccino F
Cell Growth Differ
. 1997 Sep;
8(9):1029-37.
PMID: 9300184
In the present work, we analyzed the variations in the expression and trafficking of cathepsin D (CD), a lysosomal endopeptidase, associated with the enterocytic differentiation of the human colon carcinoma...
4.
De Stefanis D, Demoz M, Dragonetti A, Houri J, Ogier-Denis E, Codogno P, et al.
Cell Tissue Res
. 1997 Jul;
289(1):109-17.
PMID: 9182605
Enterocyte-like differentiated HT-29 colon carcinoma cells were shown to contain far higher intracellular levels of activity of lysosomal cathepsins B, D, and L than their undifferentiated counterparts. In the latter,...
5.
Isidoro C, Demoz M, De Stefanis D, Baccino F, Hasilik A, Bonelli G
Int J Cancer
. 1997 Jan;
70(3):310-4.
PMID: 9033633
The kinetics of transport and the processing of procathepsin D (proCD), the precursor of a lysosomal aspartyl protease involved in tumor-cell proliferation and metastasis, were compared in normal and SV-40-...
6.
Isidoro C, Demoz M, De Stefanis D, Baccino F, Bonelli G
Int J Cancer
. 1995 Dec;
63(6):866-71.
PMID: 8847147
The relationship between cell growth and intra- and extracellular accumulation of cathepsin D (CD), a lysosomal endopeptidase involved in cell protein breakdown, was examined in cultures of normal and transformed...
7.
Houri J, Ogier-Denis E, De Stefanis D, Bauvy C, Baccino F, Isidoro C, et al.
Biochem J
. 1995 Jul;
309 ( Pt 2):521-7.
PMID: 7626015
Our previous results have demonstrated that, in undifferentiated human colon cancer HT-29 cells, a pool of glycoproteins bearing high-mannose oligosaccharides rapidly escapes the exocytic pathway to be degraded in the...
8.
Ogier-Denis E, Bauvy C, Couvineau A, De Stefanis D, Isidoro C, Codogno P
Biochem Biophys Res Commun
. 1995 Jun;
211(3):935-42.
PMID: 7598725
We have investigated the effect of a glycosylphosphatidylinositol anchor on the distribution of the soluble lysosomal enzyme cathepsin D. Only 10% of the chimeric protein (CD-GPI) could be detected on...
9.
Ogier-Denis E, Couvineau A, Maoret J, Houri J, Bauvy C, De Stefanis D, et al.
J Biol Chem
. 1995 Jan;
270(1):13-6.
PMID: 7814364
Human colon cancer HT-29 cells exhibit a differentiation-dependent autophagic-lysosomal pathway that is responsible for the degradation of a pool of newly synthesized N-linked glycoproteins in undifferentiated cells. In the present...
10.
Isidoro C, Demoz M, De Stefanis D, Mainferme F, WATTIAUX R, Baccino F
Int J Cancer
. 1995 Jan;
60(1):61-4.
PMID: 7814153
Both freshly-isolated rat hepatocytes and Morris hepatoma 7777 cells synthesized cathepsin D as a precursor that was either processed intracellular to smaller mature forms or secreted into the medium. The...