D C Spink
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Explore the profile of D C Spink including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
502
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Recent Articles
1.
Spink B, Pang S, Pentecost B, Spink D
Toxicol In Vitro
. 2002 Nov;
16(6):695-704.
PMID: 12423652
The effects of 12 non-ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol 4-hydroxylase, were investigated in MDA-MB-231 breast cancer cells. Three independent...
2.
Spink D, Zhang F, Hussain M, Katz B, Liu X, Hilker D, et al.
Chem Res Toxicol
. 2001 May;
14(5):572-81.
PMID: 11368557
Sulfate conjugates of the B-ring unsaturated estrogens, equilin, equilenin, and 8-dehydroestrone, and their 17alpha- and 17beta-dihydro analogues, constitute about 54% of Premarin (Wyeth-Ayerst), the most commonly prescribed estrogen formulation in...
3.
Spink D, Spink B, Zhuo X, Hussain M, Gierthy J, Ding X
J Steroid Biochem Mol Biol
. 2000 Nov;
74(1-2):11-8.
PMID: 11074351
Human cytochrome P450 1B1 (CYP1B1) catalyzes the hydroxylation of 17beta-estradiol (E(2)) at C-4, with a lesser activity at C-2. The E(2) 4-hydroxylase activity of human CYP1B1 was first observed in...
4.
Spink B, Katz B, Hussain M, Pang S, Connor S, Aldous K, et al.
Carcinogenesis
. 2000 Nov;
21(11):1947-57.
PMID: 11062153
In a previous study of nine human breast-derived cell lines, rates of metabolism of 17beta-estradiol (E(2)) were greatly enhanced when cultures were exposed to the aromatic hydrocarbon receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin....
5.
Gu J, Dudley C, Su T, Spink D, Zhang Q, Moss R, et al.
Biochem Biophys Res Commun
. 1999 Dec;
266(1):262-7.
PMID: 10581200
The aims of this study are to identify the sex steroid-metabolizing cytochrome P450 enzymes of the vomeronasal organ (VNO) and to determine the activities of VNO microsomes to metabolize estradiol,...
6.
Pang S, Cao J, Katz B, Hayes C, Sutter T, Spink D
Biochem Pharmacol
. 1999 Jul;
58(1):29-38.
PMID: 10403516
The effects of a series of non-ortho-substituted polychlorinated biphenyls (PCBs) on human cytochrome P450 1A1 (CYP1A1), a 17beta-estradiol (E2) 2-hydroxylase, and P450 1B1 (CYP1B1), an E2 4-hydroxylase, were investigated in...
7.
Arcaro K, Yi L, Seegal R, Vakharia D, Yang Y, Spink D, et al.
J Cell Biochem
. 1999 Feb;
72(1):94-102.
PMID: 10025670
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined...
8.
Zhuo X, Gu J, Zhang Q, Spink D, Kaminsky L, Ding X
J Pharmacol Exp Ther
. 1999 Jan;
288(2):463-71.
PMID: 9918546
Coumarin was previously found to cause tissue-selective toxicity in the olfactory mucosa (OM) of rats and mice, with rats being the more sensitive species. The aim of this study was...
9.
Spink B, Fasco M, Gierthy J, Spink D
J Cell Biochem
. 1998 Aug;
70(3):289-96.
PMID: 9706865
Elevated expression of cytochrome P450 1B1 (CYP1B1) and estradiol 4-hydroxylation have been reported to be biomarkers of tumorigenesis in humans. The aromatic hydrocarbon receptor (AhR) regulates expression of human cytochrome...
10.
Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells
Spink D, Spink B, Cao J, DePasquale J, Pentecost B, Fasco M, et al.
Carcinogenesis
. 1998 Mar;
19(2):291-8.
PMID: 9498279
Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic activation of a number of procarcinogens and the hydroxylation of 17beta-estradiol (E2) at the C-2 and C-4 positions,...