D C Dubois
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Explore the profile of D C Dubois including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
212
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Recent Articles
1.
Yang E, Almon R, Dubois D, Jusko W, Androulakis I
J Pharmacol Exp Ther
. 2007 Dec;
324(3):1243-54.
PMID: 18086872
One of the challenges in constructing biological models involves resolving meaningful data patterns from which the mathematical models will be generated. For models that describe the change of mRNA in...
2.
Sun Y, Dubois D, Almon R, Pyszczynski N, Jusko W
J Pharmacokinet Biopharm
. 1999 Sep;
26(6):619-48.
PMID: 10485078
Dose-dependent and repeated-dose effects of methylprednisolone (MPL) on down-regulation of glucocorticoid receptor messenger RNA (GR mRNA) and GR density, as well as tyrosine aminotransferase (TAT) mRNA and TAT induction by...
3.
Sagawa K, Han B, Dubois D, Murer H, Almon R, Morris M
J Pharmacol Exp Ther
. 1999 Aug;
290(3):1182-7.
PMID: 10454493
The effects of growth hormone (GH) treatment on renal sodium sulfate cotransport (NaSi-1) were studied in adult (9-10 months) and old (22-23 months) male Fischer 344 rats. All animals received...
4.
Han B, Dubois D, Boje K, Free S, Almon R
Nitric Oxide
. 1999 Aug;
3(4):281-91.
PMID: 10444367
Inducible nitric oxide synthase (iNOS) is a member of a family of primary inflammatory response genes. Quantitative measurement of iNOS mRNA levels is important for the study of gene expression...
5.
Sun Y, Dubois D, Almon R, Jusko W
J Pharmacokinet Biopharm
. 1999 Mar;
26(3):289-317.
PMID: 10098101
A fourth-generation pharmacokinetic/pharmacodynamic (PK/PD) model for receptor/genemediated effects of corticosteroids was developed. Male adrenalectomized Wistar rats received a 50 mg/kg i.v. bolus dose of methylprednisolone (MPL). Plasma concentrations of MPL,...
6.
Sun Y, McKay L, Dubois D, Jusko W, Almon R
J Pharmacol Exp Ther
. 1999 Jan;
288(2):720-8.
PMID: 9918581
Muscle wasting and excessive fat deposition are side effects attendant to chronic corticosteroid treatment. Corticosteroid immunosuppression is necessary in circumstances such as transplantation. Pharmacokinetic/pharmacodynamic (PK/PD) modeling was used to help...
7.
Sagawa K, Dubois D, Almon R, Murer H, Morris M
J Pharmacol Exp Ther
. 1998 Dec;
287(3):1056-62.
PMID: 9864292
The renal transport and fractional reabsorption of inorganic sulfate is altered under conditions of sulfate deficiency or excess. The objective of this study was to examine the cellular mechanisms of...
8.
Sagawa K, Dubois D, Han B, Almon R, Biber J, Murer H, et al.
Pflugers Arch
. 1998 Nov;
437(1):123-9.
PMID: 9817796
The sodium-dependent sulfate transporter (NaSi-1) DNA has been recently identified from rat kidney cortex. The objective of this study was to develop a quantitative assay for the NaSi-1 transporter protein....
9.
McKay L, Dubois D, Sun Y, Almon R, Jusko W
Muscle Nerve
. 1997 Oct;
20(10):1318-20.
PMID: 9324091
Common side effects of corticosteroid therapy include muscle weakness and atrophy, which are in part mediated by the induction of the enzyme glutamine synthetase. In addition, corticosteroids autoregulate their own...
10.
Dubois D, Xu Z, McKay L, Almon R, Pyszcznski N, Jusko W
J Steroid Biochem Mol Biol
. 1995 Sep;
54(5-6):237-43.
PMID: 7577705
Autoregulation of glucocorticoid receptor (GR) concentration in vivo may be an important determinant of steroid sensitivity. The dynamics of GR regulation were assessed and compared to regulation of tyrosine aminotransferase...