D C Dalgarno
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Explore the profile of D C Dalgarno including associated specialties, affiliations and a list of published articles.
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29
Citations
542
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Recent Articles
1.
Dalgarno D, Metcalf Jr C, Shakespeare W, Sawyer T
Curr Opin Drug Discov Devel
. 2009 Aug;
3(5):549-64.
PMID: 19649883
Signal transduction targets include catalytic and/or non-catalytic domains, which are critical to various aspects of cell growth, differentiation, metabolism and function, mitogenesis, motility and gene transcription. Specific examples of molecular...
2.
Sawyer T, Shakespeare W, Wang Y, Sundaramoorthi R, Huang W, Metcalf 3rd C, et al.
Med Chem
. 2006 Jun;
1(3):293-319.
PMID: 16787325
Protein phosphorylation has been exploited by Nature in profound ways to control various aspects of cell proliferation, differentiation, metabolism, survival, motility and gene transcription. Cellular signal transduction pathways involve protein...
3.
Kawahata N, Yang M, Luke G, Shakespeare W, Sundaramoorthi R, Wang Y, et al.
Bioorg Med Chem Lett
. 2001 Aug;
11(17):2319-23.
PMID: 11527723
The novel phosphotyrosine (pTyr) mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60(c-Src) (Src) tyrosine kinase. A 2.2 A...
4.
Sundaramoorthi R, Siedem C, Vu C, Dalgarno D, Laird E, Botfield M, et al.
Bioorg Med Chem Lett
. 2001 Jun;
11(13):1665-9.
PMID: 11425533
Detailed analysis of Src SH2 binding by peptides containing a novel tricarbonyl-modified pTyr moiety is described. We envisaged that Src SH2 selectivity might be obtained by exploiting the thiol group...
5.
Bohacek R, Dalgarno D, Hatada M, Jacobsen V, Lynch B, Macek K, et al.
J Med Chem
. 2001 Mar;
44(5):660-3.
PMID: 11262076
No abstract available.
6.
Violette S, Guan W, Bartlett C, Smith J, Bardelay C, Antoine E, et al.
Bone
. 2001 Feb;
28(1):54-64.
PMID: 11165943
Src, a nonreceptor tyrosine kinase, is an important regulator of osteoclast-mediated resorption. We have investigated whether compounds that bind to the Src SH2 domain inhibit Src activity in cells and...
7.
Shakespeare W, Bohacek R, Azimioara M, Macek K, Luke G, Dalgarno D, et al.
J Med Chem
. 2000 Oct;
43(21):3815-9.
PMID: 11052784
No abstract available.
8.
Shakespeare W, Bohacek R, Narula S, Azimioara M, Yuan R, Dalgarno D, et al.
Bioorg Med Chem Lett
. 1999 Nov;
9(21):3109-12.
PMID: 10560734
A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications resulted in the rapid construction...
9.
BUCHANAN J, Bohacek R, Luke G, Hatada M, Lu X, Dalgarno D, et al.
Bioorg Med Chem Lett
. 1999 Sep;
9(16):2353-8.
PMID: 10476868
The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one...
10.
Dalgarno D, Botfield M, Rickles R
Biopolymers
. 1997 Jan;
43(5):383-400.
PMID: 9566119
The ligand binding preferences, structural features, and biological function of SH3 (Src homology 3) domains are discussed. SH3 domains bind "core" Pro-rich peptide ligands (7-9 amino acids in length) in...