D Bleakman
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Explore the profile of D Bleakman including associated specialties, affiliations and a list of published articles.
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58
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1266
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Recent Articles
1.
Bleakman D, Alt A, Witkin J
CNS Neurol Disord Drug Targets
. 2007 Apr;
6(2):117-26.
PMID: 17430149
There is an increasing body of evidence implicating a role for alpha-amino-3-hydroxy-5-methyl-4 isoxazoleproprionic acid (AMPA) receptors in major depression and in the actions of antidepressant drugs. Alterations in AMPA receptors...
2.
Alt A, Witkin J, Bleakman D
Curr Pharm Des
. 2005 May;
11(12):1511-27.
PMID: 15892659
Depression affects a large percentage of the general population and can produce devastating consequences to affected individuals, families and society. Although the treatment of depression has been advanced by traditional...
3.
Sang C, Ramadan N, Wallihan R, Chappell A, Freitag F, Smith T, et al.
Cephalalgia
. 2004 Jun;
24(7):596-602.
PMID: 15196302
Glutamatergic hyperactivity is implicated migraine pathogenesis. Also, LY293558, an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate (KA) receptor antagonist, is effective in preclinical models of migraine. We therefore tested LY293558 in acute migraine. We...
4.
Alt A, Weiss B, Ogden A, Knauss J, Oler J, Ho K, et al.
Neuropharmacology
. 2004 Mar;
46(6):793-806.
PMID: 15033339
An increasing body of evidence suggests that native kainate receptors form ion channels from homomeric and heteromeric combinations of five receptor subunits: GluR5, GluR6, GluR7, KA1 and KA2. We have...
5.
Bleakman D, Gates M, Ogden A, Mackowiak M
Curr Pharm Des
. 2002 Apr;
8(10):873-85.
PMID: 11945137
Interest in kainate receptors has increased over the past few years. Our understanding of their physiology and pharmacology has improved markedly since their original cloning and expression in the early...
6.
Lauri S, Bortolotto Z, Bleakman D, Ornstein P, Lodge D, Isaac J, et al.
Neuron
. 2001 Nov;
32(4):697-709.
PMID: 11719209
The mechanisms involved in mossy fiber LTP in the hippocampus are not well established. In the present study, we show that the kainate receptor antagonist LY382884 (10 microM) is selective...
7.
Zarrinmayeh H, Bleakman D, Gates M, Yu H, Zimmerman D, Ornstein P, et al.
J Med Chem
. 2001 Jul;
44(3):302-4.
PMID: 11462971
No abstract available.
8.
Gates M, Ogden A, Bleakman D
Neuropharmacology
. 2001 Jun;
40(8):984-91.
PMID: 11406189
The present study describes the pharmacological activity of two novel positive allosteric modulators at AMPA receptors in acutely isolated rat cerebellar Purkinje neurons and cultured rat hippocampal neurons. Currents elicited...
9.
Miu P, Jarvie K, Radhakrishnan V, Gates M, Ogden A, Ornstein P, et al.
Neuropharmacology
. 2001 Jun;
40(8):976-83.
PMID: 11406188
The present study describes the activity of two novel potent and selective AMPA receptor potentiator molecules LY392098 and LY404187. LY392098 and LY404187 enhance glutamate (100 microM) stimulated ion influx through...
10.
Bleakman D
Cell Mol Life Sci
. 2001 Feb;
56(7-8):558-66.
PMID: 11212306
Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have...