D B Zamble
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Explore the profile of D B Zamble including associated specialties, affiliations and a list of published articles.
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11
Citations
495
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Recent Articles
1.
Perruchoud L, Jones M, Sutrisno A, Zamble D, Simpson A, Zhang X
Chem Sci
. 2018 Aug;
6(11):6305-6311.
PMID: 30090248
Real time and non-invasive detection of pH in live biological systems is crucial for understanding the physiological role of acid-base homeostasis and for detecting pathological conditions associated with pH imbalance....
2.
3.
Jones M, Ademi I, Yin X, Gong Y, Zamble D
Metallomics
. 2014 Dec;
7(4):662-73.
PMID: 25521693
Nickel is an essential transition metal for the survival of Helicobacter pylori in the acidic human stomach. The nickel-responsive transcriptional regulator HpNikR is important for maintaining healthy cytosolic nickel concentrations...
4.
Zamble D, Miller D, HEDDLE J, Maxwell A, WALSH C, Hollfelder F
Proc Natl Acad Sci U S A
. 2001 Jun;
98(14):7712-7.
PMID: 11427730
Microcin B17 (MccB17) is a 3.1-kDa Escherichia coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone. MccB17 inhibits its cellular target, DNA gyrase, by trapping the enzyme...
5.
HEDDLE J, Blance S, Zamble D, Hollfelder F, Miller D, Wentzell L, et al.
J Mol Biol
. 2001 Apr;
307(5):1223-34.
PMID: 11292337
Microcin B17 is a 3.1-kDa bactericidal peptide; the putative target of this antibiotic is DNA gyrase. Microcin B17 has no detectable effect on gyrase-catalysed DNA supercoiling or relaxation activities in...
6.
Zamble D, McClure C, Penner-Hahn J, WALSH C
Biochemistry
. 2000 Dec;
39(51):16190-9.
PMID: 11123948
The microcin B17 synthetase converts glycine, serine, and cysteine residues in a polypeptide precursor into oxazoles and thiazoles during the maturation of the Escherichia coli antibiotic Microcin B17. This multimeric...
7.
Zamble D, Jacks T, Lippard S
Proc Natl Acad Sci U S A
. 1998 May;
95(11):6163-8.
PMID: 9600935
Testicular cancers respond favorably to chemotherapy with the platinum-containing drug cis-diamminedichloroplatinum(II) (cisplatin). One factor that could explain the efficacy of cisplatin is the low frequency of p53 mutations observed in...
8.
Trimmer E, Zamble D, Lippard S, Essigmann J
Biochemistry
. 1998 Feb;
37(1):352-62.
PMID: 9425057
cis-Diamminedichloroplatinum(II) (cis-DDP or cisplatin) is a widely used anticancer drug that is most effective against tumors of the testis. Although cisplatin is believed to mediate its cytotoxicity through the formation...
9.
Zamble D, Mu D, Reardon J, Sancar A, Lippard S
Biochemistry
. 1996 Aug;
35(31):10004-13.
PMID: 8756462
Nucleotide excision repair is one of the many cellular defense mechanisms against the toxic effects of cisplatin. An in vitro excision repair assay employing mammalian cell-free extracts was used to...
10.
Zamble D, Lippard S
Trends Biochem Sci
. 1995 Oct;
20(10):435-9.
PMID: 8533159
Cisplatin, a DNA-damaging agent, is one of the most widely used anticancer drugs. As with all members of this class of chemotherapeutic compounds, the clinical success of cisplatin is compromised...