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D A Underhill

Explore the profile of D A Underhill including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
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11.
Fortin A, Underhill D, Gros P
Hum Mol Genet . 1997 Sep; 6(11):1781-90. PMID: 9302254
The Pax-3 protein contains two DNA-binding domains, a paired domain and a homeodomain. Mutations in Pax-3 cause Waardenburg syndrome (WS) in humans and the mouse Splotch (Sp) phenotype. In the...
12.
Underhill D, Gros P
J Biol Chem . 1997 May; 272(22):14175-82. PMID: 9162047
Pax-3 contains two structurally independent DNA-binding domains, a paired-domain and a homeodomain. Their functional interdependence has been suggested by the analysis of the Sp-delayed (Spd) mouse mutant, in which a...
13.
Zhao X, Underhill D, Hammond G
Mol Cell Endocrinol . 1997 Feb; 126(2):203-12. PMID: 9089658
The plasma transport protein for glucocorticoids, corticosteroid-binding globulin (CBG), is produced by hepatocytes, and expression of the CBG gene (Cbg) in the liver is controlled by a variety of hormones,...
14.
Vogan K, Underhill D, Gros P
Mol Cell Biol . 1996 Dec; 16(12):6677-86. PMID: 8943322
We have identified alternatively spliced isoforms of murine Pax-3 and Pax-7 which differ by the presence or absence of a single glutamine residue in a linker region which separates two...
15.
Underhill D, Hammond G
Gene . 1995 Sep; 162(2):205-11. PMID: 7557430
Corticosteroid-binding globulin (CBG) transports and modulates the bioavailability of glucocorticoids in blood plasma. It is produced predominantly by the liver, but is also produced in a complex spatial and temporal...
16.
Lepage P, Underhill D, Gros P
Virology . 1995 Jul; 210(2):244-53. PMID: 7618265
In P388/VCR-10 cells, resistance to cytotoxic drugs is caused by the overexpression of the mdr3 gene, in absence of gene amplification. The gene is transcriptionally activated following integration of a...
17.
Underhill D, Vogan K, Gros P
Proc Natl Acad Sci U S A . 1995 Apr; 92(9):3692-6. PMID: 7731966
The murine Pax-3 protein contains two DNA-binding domains, a paired domain and a homeodomain, and alterations in the Pax-3 gene are responsible for the neural tube defects observed in the...
18.
Hammond G, Smith C, Underhill D
J Steroid Biochem Mol Biol . 1991 Jan; 40(4-6):755-62. PMID: 1958574
Phylogenetic comparisons of the primary structure of corticosteroid binding globulin (CBG) have revealed several conserved domains that include sites for N-glycosylation and a region which probably represents a portion of...
19.
Hammond G, Underhill D, Rykse H, Smith C
Mol Endocrinol . 1989 Nov; 3(11):1869-76. PMID: 2608061
When a sex hormone-binding globulin (SHBG) cDNA was used to screen a human testicular cDNA library, three distinct cDNAs were isolated, one of which corresponds to the human SHBG cDNA...
20.
Underhill D, Hammond G
Mol Endocrinol . 1989 Sep; 3(9):1448-54. PMID: 2608068
The structure of the human corticosteroid binding globulin (CBG) gene has been determined, and restriction endonuclease maps of human placental DNA and cloned genomic DNA indicate that CBG is encoded...