D A Underhill
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Explore the profile of D A Underhill including associated specialties, affiliations and a list of published articles.
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24
Citations
539
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Recent Articles
1.
Veldhoen R, Banman S, Hemmerling D, Odsen R, Simmen T, Simmonds A, et al.
Oncogene
. 2012 Mar;
32(6):736-46.
PMID: 22430212
Anti-mitotic agents such as paclitaxel and docetaxel are widely used for the treatment of breast, ovarian and lung cancers. Although paclitaxel induces apoptosis, this drug also modulates autophagy. How autophagy...
2.
Craik A, Veldhoen R, Czernick M, Buckland T, Kyselytzia K, Ghosh S, et al.
Oncogene
. 2010 Jul;
29(39):5381-91.
PMID: 20603619
Antimitotic agents such as taxanes (paclitaxel and docetaxel) have greatly advanced the treatment of breast cancer, although variable patient response and drug toxicity are major limitations. Lack of validated predictive...
3.
Kibar Z, Vogan K, Groulx N, Justice M, Underhill D, Gros P
Nat Genet
. 2001 Jun;
28(3):251-5.
PMID: 11431695
Neural tube defects (NTDs) such as spina bifida and anencephaly are common congenital malformations in humans (1/1,000 births) that result from failure of the neural tube to close during embryogenesis....
4.
Kibar Z, Underhill D, Canonne-Hergaux F, Gauthier S, Justice M, Gros P
Genomics
. 2001 Jun;
72(3):331-7.
PMID: 11401449
Loop-tail (Lp) is a semidominant mutation that affects neurulation in mice. Heterozygous animals are characterized by a looped-tail appearance (pig tail) and wobbly head movements while homozygous embryos exhibit a...
5.
Underhill D, Vogan K, Underhill T, Gros P
Mamm Genome
. 2001 Feb;
12(2):172-4.
PMID: 11210189
No abstract available.
6.
Underhill D
Biochem Cell Biol
. 2000 Dec;
78(5):629-38.
PMID: 11103953
The mammalian Pax gene family comprises nine members that are characterized by a conserved DNA-binding motif, the paired domain, which was originally described in the Drosophila protein paired. Both loss-...
7.
Underhill D, Vogan K, Kibar Z, Morrison J, Rommens J, Gros P
Mamm Genome
. 2000 Aug;
11(8):633-8.
PMID: 10920231
Loop-tail (Lp) is a semidominant mutation that maps to the distal portion of mouse Chromosome (Chr) 1 and is an established model for neural tube defects (NTDs). Homozygous embryos exhibit...
8.
Underhill D, Canfield V, Dahl J, Gros P, Levenson R
Biochemistry
. 1999 Nov;
38(45):14746-51.
PMID: 10555956
We have isolated and characterized cDNA clones encoding the murine homologue of a putative fourth Na,K-ATPase alpha subunit isoform (alpha4). The predicted polypeptide is 1032 amino acids in length and...
9.
Underhill D, Mullick A, Groulx N, Beatty B, Gros P
Genomics
. 1999 Feb;
55(2):185-93.
PMID: 9933565
The mouse looptail (Lp) mutation is an established model for neural tube defects with homozygous Lp embryos showing an open neural tube from the caudal midbrain to the tip of...
10.
Fortin A, Underhill D, Gros P
Nucleic Acids Res
. 1998 Oct;
26(20):4574-81.
PMID: 9753723
Pax3 contains two structurally independent DNA-binding domains, a paired domain (PD) and a homeodomain (HD). Biochemical and mutagenesis studies have shown that both domains are functionally interdependent. In particular, it...