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Cynthia L Bristow

Explore the profile of Cynthia L Bristow including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 52
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Recent Articles
1.
Bristow C
Methods Mol Biol . 2023 Dec; 2750:185-190. PMID: 38108978
By adding purified exogenous alpha-1 antitrypsin (AAT) to peripheral blood mononuclear cells in 20% autologous serum and measuring AAT-induced cellular adherence, it was determined that purified AAT differs from plasma...
2.
Bristow C
Methods Mol Biol . 2023 Dec; 2750:175-184. PMID: 38108977
Here we describe methods for investigating alpha-1 antitrypsin (AAT) and very-low-density lipoprotein receptor (VLDLR) interactions with infectious and non-infectious HIV-1 virions. Using silencing RNA to transiently block expression of VLDLR...
3.
Bristow C
Methods Mol Biol . 2023 Dec; 2750:167-174. PMID: 38108976
Alpha-1 antitrypsin deficiency patients (AATD) have lower risk of myocardial infarction, a cardiovascular disease that is related to increased remnant cholesterol levels, but not to low-density lipoprotein (LDL) levels. However,...
4.
Bristow C
Methods Mol Biol . 2023 Dec; 2750:71-77. PMID: 38108968
Active Alpha-1 antitrypsin (AAT) circulates in blood in two isoforms in dynamic equilibrium: 1) native AAT, which binds irreversibly to neutrophil elastase, and 2) thiol-modified AAT, which binds reversibly to...
5.
Bristow C, Reeves M, Winston R
Front Oncol . 2021 Dec; 11:739080. PMID: 34900690
By promoting the cytotoxic function of CD8 T cells, immune checkpoint inhibitor therapy, programmed cell death protein-1 (PD-1), effectively inhibits tumor growth in renal cell carcinoma. Yet, as many as...
6.
Bristow C, Winston R
Front Pharmacol . 2021 Jun; 12:695971. PMID: 34177602
The abundant blood protein α1-proteinase inhibitor (α1PI, Αlpha-1, α1-antitrypsin, ) is known to bind to the active site of granule-associated human leukocyte elastase (HLE-G). Less well known is that binding...
7.
Bristow C, Winston R
Trends Immunol . 2021 Feb; 42(3):177-178. PMID: 33546997
No abstract available.
8.
Bristow C, Ferrando-Martinez S, Ruiz-Mateos E, Leal M, Winston R
Front Cell Dev Biol . 2019 Dec; 7:278. PMID: 31824943
Immune cells are, by default, migratory cells that traverse tissue for the purpose of carrying out recognition and recruitment in pathologic inflammation and infection. Members of the LDL receptor family...
9.
Bristow C, Modarresi R, Babayeva M, LaBrunda M, Mukhtarzad R, Trucy M, et al.
Discov Med . 2013 Nov; 16(89):201-18. PMID: 24229737
Dietary lipids are transported via lymph to the liver and transformed to lipoproteins which bind to members of the low density lipoprotein receptor family (LDL-RFMs). Certain LDL-RFMs, e.g., very low...
10.
Bristow C, Babayeva M, Modarresi R, McArthur C, Kumar S, Awasom C, et al.
J Vis Exp . 2012 May; (63):e3999. PMID: 22644001
There is an urgent need for affordable CD4 enumeration to monitor HIV disease. CD4 enumeration is out of reach in resource-limited regions due to the time and temperature restrictions, technical...