Curt R Freed
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Explore the profile of Curt R Freed including associated specialties, affiliations and a list of published articles.
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34
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1233
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Recent Articles
1.
Greene P, Fahn S, Eidelberg D, Bjugstad K, Breeze R, Freed C
NPJ Parkinsons Dis
. 2021 Apr;
7(1):38.
PMID: 33893319
Cell transplants are being developed for patients with Parkinson disease (PD) who have insufficient benefit with standard medical treatment. We describe the clinical features of five patients who developed persistent...
2.
Zhou W, Barkow J, Freed C
PLoS One
. 2017 Dec;
12(12):e0190160.
PMID: 29272304
Exercise has been recommended to improve motor function in Parkinson patients, but its value in altering progression of disease is unknown. In this study, we examined the neuroprotective effects of...
3.
Gao L, Zhou W, Symmes B, Freed C
PLoS One
. 2016 Aug;
11(8):e0160847.
PMID: 27512998
Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. To understand the molecular mechanisms of the disease, an in vitro model is important. In the...
4.
Bahmed K, Messier E, Zhou W, Tuder R, Freed C, Chu H, et al.
Am J Respir Cell Mol Biol
. 2016 Apr;
55(3):439-49.
PMID: 27093578
Cigarette smoke (CS) is a main source of oxidative stress and a key risk factor for emphysema, which consists of alveolar wall destruction. Alveolar type (AT) II cells are in...
5.
Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al.
Mol Pharmacol
. 2015 Sep;
88(6):1045-54.
PMID: 26405178
A potential cause of neurodegenerative diseases, including Parkinson's disease (PD), is protein misfolding and aggregation that in turn leads to neurotoxicity. Targeting Hsp90 is an attractive strategy to halt neurodegenerative...
6.
Jenkins P, Laughter M, Lee D, Lee Y, Freed C, Park D
Nanoscale Res Lett
. 2015 Jun;
10(1):972.
PMID: 26071111
Despite major advances in the pathophysiological understanding of peripheral nerve damage, the treatment of nerve injuries still remains an unmet medical need. Nerve guidance conduits present a promising treatment option...
7.
Yun D, Lee Y, Laughter M, Freed C, Park D
Macromol Biosci
. 2015 Jun;
15(9):1206-11.
PMID: 26033933
To find the first restorative treatment for spinal cord injury (SCI), researchers have focused on stem cell therapies. However, one obstacle is the lack of an implantable cell scaffold that...
8.
Yun D, Famili A, Lee Y, Jenkins P, Freed C, Park D
J Biomater Sci Polym Ed
. 2013 Nov;
25(4):354-69.
PMID: 24279744
Nerve function recovery is a major technical challenge in the rehabilitation of patients suffering from severe neuropathies. Facilitating functional recovery requires the creation of a growth-permissive environment that directs the...
9.
Lee K, Zhou W, Scott-McKean J, Emmerling K, Cai G, Krah D, et al.
PLoS One
. 2013 Jan;
7(12):e53010.
PMID: 23285249
After primary infection, varicella-zoster virus (VZV) establishes latency in neurons of the dorsal root and trigeminal ganglia. Many questions concerning the mechanism of VZV pathogenesis remain unanswered, due in part...
10.
Freed C, Zhou W, Breeze R
Neurotherapeutics
. 2011 Oct;
8(4):549-61.
PMID: 21997523
Transplantation of human fetal dopamine neurons into the brain of Parkinson's disease patients started in the late 1980s, less than 10 years after experiments in rats showed that embryonic dopamine...