Cristina Guardia-Laguarta
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Explore the profile of Cristina Guardia-Laguarta including associated specialties, affiliations and a list of published articles.
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26
Citations
1742
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Recent Articles
1.
Barbuti P, Guardia-Laguarta C, Yun T, Chatila Z, Flowers X, Santos B, et al.
bioRxiv
. 2024 Jul;
PMID: 38948777
The protein alpha-synuclein (αSyn) plays a critical role in the pathogenesis of synucleinopathy, which includes Parkinson's disease and multiple system atrophy, and mounting evidence suggests that lipid dyshomeostasis is a...
2.
Avisar H, Guardia-Laguarta C, Surface M, Papagiannakis N, Maniati M, Antonellou R, et al.
NPJ Parkinsons Dis
. 2022 Apr;
8(1):52.
PMID: 35468903
Lipid profiles in biological fluids from patients with Parkinson's disease (PD) are increasingly investigated in search of biomarkers. However, the lipid profiles in genetic PD remain to be determined, a...
3.
Avisar H, Guardia-Laguarta C, Area-Gomez E, Surface M, Chan A, Alcalay R, et al.
J Parkinsons Dis
. 2021 Apr;
11(3):1141-1155.
PMID: 33814463
Background: The role of the lipidome as a biomarker for Parkinson's disease (PD) is a relatively new field that currently only focuses on PD diagnosis. Objective: To identify a relevant...
4.
Montesinos J, Pera M, Larrea D, Guardia-Laguarta C, Agrawal R, Velasco K, et al.
EMBO J
. 2020 Sep;
39(20):e103791.
PMID: 32865299
The link between cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationship relates to Alzheimer's disease (AD) pathogenesis, is still unknown. Cellular cholesterol levels are...
5.
Montesinos J, Guardia-Laguarta C, Area-Gomez E
Curr Opin Clin Nutr Metab Care
. 2020 Feb;
23(2):68-75.
PMID: 32004239
Purpose Of Review: The purpose of this brief review is to gain an understanding on the multiple roles that lipids exert on the brain, and to highlight new ideas in...
6.
Guardia-Laguarta C, Liu Y, Lauritzen K, Erdjument-Bromage H, Martin B, Swayne T, et al.
J Neurosci
. 2019 Jul;
39(36):7074-7085.
PMID: 31300519
Maintaining a pool of functional mitochondria requires degradation of damaged ones within the cell. PINK1 is critical in this quality-control process: loss of mitochondrial membrane potential causes PINK1 to accumulate...
7.
Larrea D, Pera M, Gonnelli A, Quintana-Cabrera R, Akman H, Guardia-Laguarta C, et al.
Hum Mol Genet
. 2019 Jan;
28(11):1782-1800.
PMID: 30649465
Charcot-Marie-Tooth disease (CMT) type 2A is a form of peripheral neuropathy, due almost exclusively to dominant mutations in the nuclear gene encoding the mitochondrial protein mitofusin-2 (MFN2). However, there is...
8.
Area-Gomez E, Guardia-Laguarta C, Schon E, Przedborski S
J Clin Invest
. 2019 Jan;
129(1):34-45.
PMID: 30601141
Mitochondrial respiratory deficiencies have been observed in numerous neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. For decades, these reductions in oxidative phosphorylation (OxPhos) have been presumed to trigger an...
9.
Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco K, Agrawal R, et al.
EMBO J
. 2017 Oct;
36(22):3356-3371.
PMID: 29018038
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by...
10.
Liu Y, Guardia-Laguarta C, Yin J, Erdjument-Bromage H, Martin B, James M, et al.
Cell Rep
. 2017 Jul;
20(1):30-39.
PMID: 28683321
Along with Parkin, PINK1 plays a critical role in maintaining mitochondrial quality control. Although PINK1 is expressed constitutively, its level is kept low in healthy mitochondria by polyubiquitination and ensuing...