Cristina-Maria Cruciat
Overview
Explore the profile of Cristina-Maria Cruciat including associated specialties, affiliations and a list of published articles.
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14
Citations
3320
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Recent Articles
1.
Hirth A, Fatti E, Netz E, Acebron S, Papageorgiou D, Svorinic A, et al.
Genome Res
. 2024 Jul;
34(6):952-966.
PMID: 38986579
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins...
2.
Fatti E, Hirth A, Svorinic A, Gunther M, Stier G, Cruciat C, et al.
Sci Signal
. 2023 Apr;
16(782):eabp8923.
PMID: 37098120
DDX RNA helicases promote RNA processing, but DDX3X also activates casein kinase 1 (CK1ε). We show that other DDX proteins also stimulate the protein kinase activity of CK1ε and that...
3.
Strecker V, Kadeer Z, Heidler J, Cruciat C, Angerer H, Giese H, et al.
Biochim Biophys Acta
. 2016 Apr;
1863(7 Pt A):1643-52.
PMID: 27091403
Here we identified a hydrophobic 6.4kDa protein, Cox26, as a novel component of yeast mitochondrial supercomplex comprising respiratory complexes III and IV. Multi-dimensional native and denaturing electrophoretic techniques were used...
4.
Cruciat C
Curr Opin Cell Biol
. 2014 Sep;
31:46-55.
PMID: 25200911
Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting as both Wnt activators...
5.
Cruciat C, Dolde C, de Groot R, Ohkawara B, Reinhard C, Korswagen H, et al.
Science
. 2013 Feb;
339(6126):1436-41.
PMID: 23413191
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified...
6.
Cruciat C, Niehrs C
Cold Spring Harb Perspect Biol
. 2012 Oct;
5(3):a015081.
PMID: 23085770
Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic development and adult homeostasis. Wnt signaling is modulated by a number of evolutionarily conserved inhibitors and activators....
7.
Glinka A, Dolde C, Kirsch N, Huang Y, Kazanskaya O, Ingelfinger D, et al.
EMBO Rep
. 2011 Sep;
12(10):1055-61.
PMID: 21909076
R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R-spondins bind to the...
8.
Huhn S, Ingelfinger D, Lorenzo Bermejo J, Bevier M, Pardini B, Naccarati A, et al.
Int J Mol Epidemiol Genet
. 2011 May;
2(1):36-50.
PMID: 21537400
Colorectal cancer (CRC) is a complex disease related to environmental and genetic risk factors. Several studies have shown that susceptibility to complex diseases can be mediated by ancestral alleles. Using...
9.
Liang J, Fu Y, Cruciat C, Jia S, Wang Y, Tong Z, et al.
Mol Cell Biol
. 2011 May;
31(13):2577-90.
PMID: 21536646
Wnt/β-catenin signaling is fundamental in embryogenesis and tissue homeostasis in metazoans. Upon Wnt stimulation, cognate coreceptors LRP5 and LRP6 ([LRP5/6] low-density lipoprotein receptor-related proteins 5 and 6) are activated via...
10.
Cruciat C, Ohkawara B, Acebron S, Karaulanov E, Reinhard C, Ingelfinger D, et al.
Science
. 2010 Jan;
327(5964):459-63.
PMID: 20093472
Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood....