Corrado Santocanale
Overview
Explore the profile of Corrado Santocanale including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
33
Citations
810
Followers
0
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Recent Articles
1.
Goder A, Maric C, Rainey M, OConnor A, Cazzaniga C, Shamavu D, et al.
J Cell Biol
. 2024 Jun;
223(8).
PMID: 38865090
CDC7 kinase is crucial for DNA replication initiation and is involved in fork processing and replication stress response. Human CDC7 requires the binding of either DBF4 or DRF1 for its...
2.
Cazzaniga C, Goder A, Rainey M, Quinlan A, Coughlan S, Bernard S, et al.
FEBS J
. 2024 Mar;
291(14):3147-3168.
PMID: 38555567
Drugs that block DNA replication prevent cell proliferation, which may result in anticancer activity. The latter is dependent on the drug's mode of action as well as on cell type-dependent...
3.
Goder A, Quinlan A, Rainey M, Bennett D, Shamavu D, Corso J, et al.
iScience
. 2023 Jun;
26(6):106951.
PMID: 37378325
CDC7 kinase is crucial for DNA replication initiation and fork processing. CDC7 inhibition mildly activates the ATR pathway, which further limits origin firing; however, to date the relationship between CDC7...
4.
Rainey M, Bennett D, ODea R, Zanchetta M, Voisin M, Seoighe C, et al.
Cell Rep
. 2020 Sep;
32(9):108096.
PMID: 32877678
DNA replication initiates from multiple origins, and selective CDC7 kinase inhibitors (CDC7is) restrain cell proliferation by limiting origin firing. We have performed a CRISPR-Cas9 genome-wide screen to identify genes that,...
5.
Rainey M, Quinlan A, Cazzaniga C, Mijic S, Martella O, Krietsch J, et al.
EMBO Rep
. 2020 Jun;
21(8):e48920.
PMID: 32496651
The CDC7 kinase is essential for the activation of DNA replication origins and has been implicated in the replication stress response. Using a highly specific chemical inhibitor and a chemical...
6.
ODea R, Santocanale C
J Cell Sci
. 2020 Jan;
133(3).
PMID: 31964704
In order to prevent the deleterious effects of genotoxic agents, cells have developed complex surveillance mechanisms and DNA repair pathways that allow them to maintain genome integrity. The ubiquitin-specific protease...
7.
Reilly E, Dhami S, Baev D, Ortutay C, Halpin-McCormick A, Morrell R, et al.
Sci Rep
. 2018 Oct;
8(1):15752.
PMID: 30361682
Acute myeloid leukaemia (AML) is an aggressive cancer with 50-75% of patients relapsing even after successful chemotherapy. The role of the bone marrow microenvironment (BMM) in protecting AML cells from...
8.
Rainey M, Quachthithu H, Gaboriau D, Santocanale C
ACS Chem Biol
. 2017 Jun;
12(7):1893-1902.
PMID: 28560864
The CDC7 kinase, by phosphorylating the MCM DNA helicase, is a key switch for DNA replication initiation. ATP competitive CDC7 inhibitors are being developed as potential anticancer agents; however how...
9.
Wu K, Wang G, FitzGerald J, Quachthithu H, Rainey M, Cattaneo A, et al.
Nucleic Acids Res
. 2016 Jul;
44(18):8786-8798.
PMID: 27407105
In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and...
10.
McGarry E, Gaboriau D, Rainey M, Restuccia U, Bachi A, Santocanale C
Cancer Res
. 2016 Feb;
76(8):2384-93.
PMID: 26921344
Coordination of the multiple processes underlying DNA replication is key for maintaining genome stability and preventing tumorigenesis. CLASPIN, a critical player in replication fork stabilization and checkpoint responses, must be...