Cornelia C Siebrands
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Explore the profile of Cornelia C Siebrands including associated specialties, affiliations and a list of published articles.
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11
Citations
263
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Recent Articles
1.
Nebel M, Schwoerer A, Warszta D, Siebrands C, Limbrock A, Swarbrick J, et al.
J Biol Chem
. 2013 Apr;
288(22):16017-30.
PMID: 23564460
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardiac...
2.
Li L, Siebrands C, Yang Z, Zhang L, Guse A, Zhang L
Org Biomol Chem
. 2010 May;
8(8):1843-8.
PMID: 20449488
A purine nucleobase-simplified cyclic ADP ribose (cADPR) analogue was synthesized, in which a 1,2,3-triazole-4-amide was constructed, instead of a purine moiety, and the northern ribose was replaced by an ether...
3.
Kirchberger T, Moreau C, Wagner G, Fliegert R, Siebrands C, Nebel M, et al.
Biochem J
. 2009 Jun;
422(1):139-49.
PMID: 19492987
cADPR (cyclic ADP-ribose) is a universal Ca(2+) mobilizing second messenger. In T-cells cADPR is involved in sustained Ca(2+) release and also in Ca(2+) entry. Potential mechanisms for the latter include...
4.
Partida-Sanchez S, Gasser A, Fliegert R, Siebrands C, Dammermann W, Shi G, et al.
J Immunol
. 2007 Nov;
179(11):7827-39.
PMID: 18025229
The ectoenzyme CD38 catalyzes the production of cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from its substrate, NAD(+). Both products of the CD38 enzyme reaction play important roles in signal transduction,...
5.
Schwoerer A, Blutner C, Brandt S, Binder S, Siebrands C, Ehmke H, et al.
Anesthesiology
. 2007 Apr;
106(5):967-76.
PMID: 17457128
Background: The cardiac safety of droperidol given at antiemetic doses is a matter of debate. Although droperidol potently inhibits human ether-a-go-go-related gene (HERG) channels, the molecular mode of this interaction...
6.
Siebrands C, Friederich P
Anesthesiology
. 2007 Feb;
106(3):523-31.
PMID: 17325511
Background: Local anesthetics interact with human ether-a-go-go-related gene (HERG) channels via the aromatic amino acids Y652 and F656 in the S6 region. This study aimed to establish whether the residues...
7.
Siebrands C, Binder S, Eckhoff U, Schmitt N, Friederich P
Anesthesiology
. 2006 Aug;
105(3):511-20.
PMID: 16931984
Background: Anesthesia in patients with long QT syndrome (LQTS) is a matter of concern. Congenital LQTS is most frequently caused by mutations in KCNQ1 (Kv7.1), whereas drug-induced LQTS is a...
8.
Sanger J, Kang S, Siebrands C, Freeman N, Du A, Wang J, et al.
J Muscle Res Cell Motil
. 2006 Feb;
26(6-8):343-54.
PMID: 16465476
Building a myofibril from its component proteins requires the interactions of many different proteins in a process whose details are not understood. Several models have been proposed to provide a...
9.
Solth A, Siebrands C, Friederich P
Anesthesiology
. 2005 Sep;
103(4):796-804.
PMID: 16192772
Background: The transient outward current Ito is an important repolarizing K current in human ventricular myocardium mediated by Kv4.3 and KChIP2.2 subunits. Inhibition of Ito by amino-amide local anesthetics may...
10.
Siebrands C, Schmitt N, Friederich P
Anesthesiology
. 2005 Jun;
103(1):102-12.
PMID: 15983462
Background: Human ether-a-go-go-related gene (HERG) potassium channels constitute a potential target involved in cardiotoxic side effects of amino-amide local anesthetics. The molecular interaction site of these low-affinity blockers with HERG...