Corinna Hintermair
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Explore the profile of Corinna Hintermair including associated specialties, affiliations and a list of published articles.
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12
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966
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Recent Articles
1.
Nemec C, Singh A, Ali A, Tseng S, Syal K, Ringelberg K, et al.
Nat Chem Biol
. 2019 Jan;
15(2):123-131.
PMID: 30598543
Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) governs stage-specific interactions with different cellular machines. The CTD consists of YSPTSPS heptad repeats...
2.
Weidle U, Dickopf S, Hintermair C, Kollmorgen G, Birzele F, Brinkmann U
Cancer Genomics Proteomics
. 2017 Dec;
15(1):17-39.
PMID: 29275360
Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a...
3.
Nemec C, Yang F, Gilmore J, Hintermair C, Ho Y, Tseng S, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(20):E3944-E3953.
PMID: 28465432
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) orchestrates dynamic recruitment of specific cellular machines during different stages of transcription. Signature phosphorylation patterns of...
4.
Hintermair C, Voss K, Forne I, Heidemann M, Flatley A, Kremmer E, et al.
Sci Rep
. 2016 Jun;
6:27401.
PMID: 27264542
Dynamic phosphorylation of Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 heptad-repeats in the C-terminal domain (CTD) of the large subunit coordinates progression of RNA polymerase (Pol) II through the transcription cycle. Here, we describe an M...
5.
Voss K, Forne I, Descostes N, Hintermair C, Schuller R, Maqbool M, et al.
Transcription
. 2015 Nov;
6(5):91-101.
PMID: 26566685
Dynamic modification of heptad-repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 of RNA polymerase II (RNAPII) C-terminal domain (CTD) regulates transcription-coupled processes. Mass spectrometry analysis revealed that K7-residues in non-consensus repeats of...
6.
Bosken C, Farnung L, Hintermair C, Schachter M, Vogel-Bachmayr K, Blazek D, et al.
Nat Commun
. 2014 Mar;
5:3505.
PMID: 24662513
Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for...
7.
Heidemann M, Hintermair C, Voss K, Eick D
Biochim Biophys Acta
. 2012 Sep;
1829(1):55-62.
PMID: 22982363
The eukaryotic RNA polymerase II (RNAPII) catalyzes the transcription of all protein encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII has evolved a unique...
8.
Mayer A, Heidemann M, Lidschreiber M, Schreieck A, Sun M, Hintermair C, et al.
Science
. 2012 Jun;
336(6089):1723-5.
PMID: 22745433
In different phases of the transcription cycle, RNA polymerase (Pol) II recruits various factors via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the sequence Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7). We...
9.
Hintermair C, Heidemann M, Koch F, Descostes N, Gut M, Gut I, et al.
EMBO J
. 2012 May;
31(12):2784-97.
PMID: 22549466
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation...
10.
Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M, Hsu C, Gorsler T, et al.
Cancer Res
. 2011 Aug;
71(17):5739-53.
PMID: 21862633
The estrogen receptor-α (ERα) determines the phenotype of breast cancers where it serves as a positive prognostic indicator. ERα is a well-established target for breast cancer therapy, but strategies to...