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Corey Giles

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Recent Articles
1.
Stevens H, McFadyen J, Mellett N, Lynn D, Duong T, Giles C, et al.
Res Pract Thromb Haemost . 2025 Mar; 9(1):102677. PMID: 40041449
Background: VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such as ChAdOx1-S (Oxford/AstraZeneca) vaccination. The syndrome is characterized by thrombosis with...
2.
Neth B, Huynh K, Giles C, Wang T, Mellett N, Duong T, et al.
Commun Med (Lond) . 2025 Jan; 5(1):11. PMID: 39779882
Background: Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset and progression. Although previous studies have suggested that certain diets...
3.
Zhao S, Giles C, Huynh K, Kettunen J, Jarvelin M, Kahonen M, et al.
Anal Chem . 2024 Dec; 96(52):20362-20370. PMID: 39680883
Applications of advanced omics methodologies are increasingly popular in biomedicine. However, large-scale studies aiming at clinical translation are typically siloed to single technologies. Here, we present the first comprehensive large-scale...
4.
Lin H, Yang X, Centenera M, Huynh K, Giles C, Dehairs J, et al.
JCO Precis Oncol . 2024 Jul; 8():e2400260. PMID: 39074346
Purpose: Intense androgen deprivation therapy (ADT) with androgen receptor pathway inhibitors (ARPIs) before radical prostatectomy (RP) produced favorable pathologic responses in approximately 20% of patients. The molecular reason for the...
5.
Wu J, Giles C, Dakic A, Beyene H, Huynh K, Wang T, et al.
J Am Coll Cardiol . 2024 Jul; 84(5):434-446. PMID: 39048275
Background: Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score (FRS) may underperform within the diverse intermediate-risk group,...
6.
Wang T, Beyene H, Yi C, Cinel M, Mellett N, Olshansky G, et al.
EBioMedicine . 2024 Jun; 105:105199. PMID: 38905750
Background: Metabolic ageing biomarkers may capture the age-related shifts in metabolism, offering a precise representation of an individual's overall metabolic health. Methods: Utilising comprehensive lipidomic datasets from two large independent...
7.
Beyene H, Huynh K, Wang T, Paul S, Cinel M, Mellett N, et al.
EBioMedicine . 2024 Jun; 105:105187. PMID: 38861870
Background: Decreased levels of circulating ethanolamine plasmalogens [PE(P)], and a concurrent increase in phosphatidylethanolamine (PE) are consistently reported in various cardiometabolic conditions. Here we devised, a plasmalogen score (Pls Score)...
8.
Yeung N, Li T, Lin H, Timmins H, Goldstein D, Harrison M, et al.
JCO Precis Oncol . 2024 May; 8:e2300690. PMID: 38691814
Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of cytotoxic cancer treatment, often necessitating dose reduction (DR) or chemotherapy discontinuation (CD). Studies on peripheral neuropathy related to chemotherapy,...
9.
Morgan P, Pernes G, Huynh K, Giles C, Paul S, Smith A, et al.
Nat Cell Biol . 2024 Apr; 26(4):645-659. PMID: 38589531
The cellular lipidome comprises thousands of unique lipid species. Here, using mass spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and mouse immune cells ( www.cellularlipidatlas.com ). Using...
10.
Dakic A, Wu J, Wang T, Huynh K, Mellett N, Duong T, et al.
Nat Commun . 2024 Feb; 15(1):1540. PMID: 38378775
Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic and mass spectrometric resolution of newer platforms, has...