Cor Breukel
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Explore the profile of Cor Breukel including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
878
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Recent Articles
1.
Jansen N, Linnenbank C, Schenke M, Voskuyl R, Jorge M, Krivoshein G, et al.
Neurobiol Dis
. 2024 Oct;
202:106714.
PMID: 39448040
The mechanisms of initiation of spreading depolarization (SD) are understudied due to a paucity of disease models with spontaneously occurring events. We here present a novel mouse model of familial...
2.
Vukic M, Chouaref J, Della Chiara V, Dogan S, Ratner F, Hogenboom J, et al.
Sci Adv
. 2024 Feb;
10(6):eadk3384.
PMID: 38335290
Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact of DNA methylation loss on transcription has not been investigated. Here, we...
3.
Legrain S, Su D, Gaignage M, Breukel C, Claassens J, Brouwers C, et al.
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445732
Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated...
4.
Jansen N, Dehghani A, Breukel C, Tolner E, van den Maagdenberg A
Epilepsia
. 2020 Mar;
61(4):e30-e36.
PMID: 32190912
Early onset seizures are a hallmark of Dravet syndrome. Previous studies in rodent models have shown that the epileptic phenotype is caused by loss-of-function of voltage-gated Na 1.1 sodium channels,...
5.
Sow H, Benonisson H, Brouwers C, Linssen M, Camps M, Breukel C, et al.
Sci Rep
. 2020 Mar;
10(1):3933.
PMID: 32127568
The use of Trastuzumab (Herceptin), a monoclonal antibody (mAb) targeting HER2/neu, results in an increased median survival in Her2 breast cancer patients. The tumour mutational burden and the presence of...
6.
Jansen N, Dehghani A, Linssen M, Breukel C, Tolner E, van den Maagdenberg A
Ann Clin Transl Neurol
. 2019 Dec;
7(1):132-138.
PMID: 31880072
Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events - the electrophysiological correlate of the migraine aura - in animals by using the first generated familial...
7.
Benonisson H, Sow H, Breukel C, Claassens J, Brouwers C, Linssen M, et al.
J Immunol
. 2018 Nov;
201(12):3741-3749.
PMID: 30397036
Therapy with tumor-specific Abs is common in the clinic but has limited success against solid malignancies. We aimed at improving the efficacy of this therapy by combining a tumor-specific Ab...
8.
Sow H, Benonisson H, Breukel C, Visser R, Verhagen O, Bentlage A, et al.
Int J Cancer
. 2018 Sep;
144(2):345-354.
PMID: 30259976
Immunomodulatory antibodies blocking interactions of coinhibitory receptors to their ligands such as CTLA-4, PD1 and PD-L1 on immune cells have shown impressive therapeutic efficacy in clinical studies. The therapeutic effect...
9.
Benonisson H, Sow H, Breukel C, Claassens J, Brouwers C, Linssen M, et al.
Oncotarget
. 2018 Jul;
9(50):29392-29402.
PMID: 30034625
Cytomegalovirus (CMV)-based vaccine vectors are promising vaccine platforms because they induce strong and long-lasting immune responses. Recently it has been shown that vaccination with a mouse CMV (MCMV) vector expressing...
10.
Fransen M, Benonisson H, van Maren W, Sow H, Breukel C, Linssen M, et al.
J Immunol
. 2018 Mar;
200(8):2615-2626.
PMID: 29523656
By their interaction with IgG immune complexes, FcγR and complement link innate and adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG downstream effector functions are often impaired, as well...