Cor Breukel
Overview
Explore the profile of Cor Breukel including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
878
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Recent Articles
11.
Veltrop M, Van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, et al.
PLoS One
. 2018 Feb;
13(2):e0193289.
PMID: 29466448
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease generally caused by reading frame disrupting mutations in the DMD gene resulting in loss of functional dystrophin protein. The reading frame...
12.
de Roo J, Breukel C, Chhatta A, Linssen M, Vloemans S, Salvatori D, et al.
Genesis
. 2017 Sep;
55(10).
PMID: 28875532
The canonical Wnt signalling pathway has been implicated in organogenesis and self-renewal of essentially all stem cell systems. In vivo reporter systems are crucial to assess the role of Wnt...
13.
Rutten J, Klever R, Hegeman I, Poole D, Dauwerse H, Broos L, et al.
Acta Neuropathol Commun
. 2015 Dec;
3:89.
PMID: 26715087
Introduction: CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein accumulation...
14.
Legrain S, Su D, Breukel C, Detalle L, Claassens J, van der Kaa J, et al.
J Immunol
. 2015 Sep;
195(9):4171-5.
PMID: 26385523
IgM anti-mouse platelet autoantibodies cause thrombocytopenia by mediating uptake of opsonized thrombocytes, whereas IgM anti-erythrocyte autoantibodies induce anemia through a phagocytosis-independent cell destruction. In this article, we show that infection...
15.
Yilmaz-Elis A, Ramirez J, Asmawidjaja P, van der Kaa J, Mus A, Brem M, et al.
J Immunol
. 2014 May;
192(12):5540-7.
PMID: 24842758
Extensive analysis of a variety of arthritis models in germline KO mice has revealed that all four receptors for the Fc part of IgG (FcγR) play a role in the...
16.
Anvar S, van der Gaag K, van der Heijden J, Veltrop M, Vossen R, de Leeuw R, et al.
Bioinformatics
. 2014 Feb;
30(12):1651-9.
PMID: 24532718
Motivation: Advances in sequencing technologies and computational algorithms have enabled the study of genomic variants to dissect their functional consequence. Despite this unprecedented progress, current tools fail to reliably detect...
17.
Yilmaz-Elis A, Aartsma-Rus A, t Hoen P, Safdar H, Breukel C, van Vlijmen B, et al.
Mol Ther Nucleic Acids
. 2013 Jan;
2:e66.
PMID: 23340324
The cytokine interleukin 1(IL-1) initiates a wide range of proinflammatory cascades and its inhibition has been shown to decrease inflammation in a variety of diseases. IL-1 receptor accessory protein (IL-1RAcP)...
18.
Boross P, Arandhara V, Martin-Ramirez J, Santiago-Raber M, Carlucci F, Flierman R, et al.
J Immunol
. 2011 Jul;
187(3):1304-13.
PMID: 21724994
FcγRIIB-deficient mice generated in 129 background (FcγRIIB(129)(-/-)) if back-crossed into C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in mice and humans, the Fcγr2b gene is located...
19.
Robanus-Maandag E, Koelink P, Breukel C, Salvatori D, Jagmohan-Changur S, Bosch C, et al.
Carcinogenesis
. 2010 Feb;
31(5):946-52.
PMID: 20176656
Mutations of the adenomatous polyposis coli (APC) gene predispose individuals to familial adenomatous polyposis (FAP), characterized by multiple tumours in the large intestine. Most mouse models heterozygous for truncating mutant...
20.
Boross P, Breukel C, van Loo P, van der Kaa J, Claassens J, Bujard H, et al.
Genesis
. 2009 Jul;
47(11):729-35.
PMID: 19621440
The generation of cell type specific inducible Cre transgenic mice is the most challenging and limiting part in the development of spatio-temporally controlled knockout mouse models. Here we report the...