Constantinos G Broustas
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Explore the profile of Constantinos G Broustas including associated specialties, affiliations and a list of published articles.
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25
Citations
471
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Recent Articles
11.
Mukherjee S, Grilj V, Broustas C, Ghandhi S, Harken A, Garty G, et al.
Radiat Res
. 2019 Jun;
192(2):189-199.
PMID: 31237816
In the possible event of a detonation of an improvised nuclear device (IND), the immediate radiation would consist of both photons (gamma rays) and neutrons. Since neutrons generally have a...
12.
Broustas C, Hopkins K, Panigrahi S, Wang L, Virk R, Lieberman H
Carcinogenesis
. 2018 Oct;
40(1):164-172.
PMID: 30295739
RAD9A plays an important role in prostate tumorigenesis and metastasis-related phenotypes. The protein classically functions as part of the RAD9A-HUS1-RAD1 complex but can also act independently. RAD9A can selectively transactivate...
13.
Lieberman H, Rai A, Friedman R, Hopkins K, Broustas C
Transl Cancer Res
. 2018 Aug;
7(Suppl 6):S651-S661.
PMID: 30079300
Prostate cancer is a complex disease, with multiple subtypes and clinical presentations. Much progress has been made in recent years to understand the underlying genetic basis that drives prostate cancer....
14.
Broustas C, Harken A, Garty G, Amundson S
BMC Genomics
. 2018 Jun;
19(1):504.
PMID: 29954325
Background: Radiation exposure due to the detonation of an improvised nuclear device remains a major security concern. Radiation from such a device involves a combination of photons and neutrons. Although...
15.
Broustas C, Xu Y, Harken A, Chowdhury M, Garty G, Amundson S
Radiat Res
. 2017 Feb;
187(4):433-440.
PMID: 28140791
The detonation of an improvised nuclear device would produce prompt radiation consisting of both photons (gamma rays) and neutrons. While much effort in recent years has gone into the development...
16.
Lieberman H, Panigrahi S, Hopkins K, Wang L, Broustas C
Radiat Res
. 2017 Feb;
187(4):424-432.
PMID: 28140789
The way cells respond to DNA damage is important since inefficient repair or misrepair of lesions can have deleterious consequences, including mutation, genomic instability, neurodegenerative disorders, premature aging, cancer or...
17.
Broustas C, Xu Y, Harken A, Garty G, Amundson S
BMC Genomics
. 2017 Jan;
18(1):2.
PMID: 28049433
Background: In the event of an improvised nuclear device detonation, the prompt radiation exposure would consist of photons plus a neutron component that would contribute to the total dose. As...
18.
Broustas C, Lieberman H
Prostate
. 2014 Aug;
74(14):1359-70.
PMID: 25111005
Background: Mouse embryonic stem cells null for Rad9 are sensitive to deleterious effects of ionizing radiation exposure. Likewise, integrin β1 is a known radioprotective factor. Previously, we showed that RAD9...
19.
Broustas C, Lieberman H
Radiat Res
. 2014 Jan;
181(2):111-30.
PMID: 24397478
DNA damage response genes play vital roles in the maintenance of a healthy genome. Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant downregulation, are associated...
20.
Broustas C, Zhu A, Lieberman H
J Biol Chem
. 2012 Oct;
287(49):41324-33.
PMID: 23066031
Rad9 as part of the Rad9-Hus1-Rad1 complex is known to participate in cell cycle checkpoint activation and DNA repair. However, Rad9 can act as a sequence-specific transcription factor, modulating expression...