Conchita Tros de Ilarduya
Overview
Explore the profile of Conchita Tros de Ilarduya including associated specialties, affiliations and a list of published articles.
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45
Citations
548
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Recent Articles
1.
Rivero-Barbarroja G, Lopez-Fernandez J, Juarez-Gonzalvez I, Fernandez-Clavero C, Di Giorgio C, Velaz I, et al.
Carbohydr Polym
. 2024 Nov;
347:122776.
PMID: 39487000
We introduce an innovative β-cyclodextrin (βCD)-prototype for delivering nucleic acids: "geometrically frustrated amphiphiles (GFAs)." GFAs are designed with cationic centers evenly distributed across the primary O6 and secondary O2 positions...
2.
Ortega-Caballero F, Santana-Armas M, Tros de Ilarduya C, Di Giorgio C, Tripier R, Le Bris N, et al.
J Mater Chem B
. 2024 Mar;
12(14):3445-3452.
PMID: 38502035
A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based macrocycles (cyclotrehalans) comprising linear or cyclic polyamine heads have been synthesized through procedures that exploit...
3.
Carbajo-Gordillo A, Lopez-Fernandez J, Benito J, Jimenez Blanco J, Santana-Armas M, Marcelo G, et al.
Macromol Rapid Commun
. 2022 Apr;
43(11):e2200145.
PMID: 35426201
A robust strategy is reported to build perfectly monodisperse star polycations combining a trehalose-based cyclooligosaccharide (cyclotrehalan, CT) central core onto which oligoethyleneimine radial arms are installed. The architectural perfection of...
4.
Sanchez-Arribas N, Martinez-Negro M, Aicart-Ramos C, Tros de Ilarduya C, Aicart E, Guerrero-Martinez A, et al.
Pharmaceutics
. 2021 Jun;
13(5).
PMID: 34063469
Ample evidence exists on the role of interleukin-12 (IL-12) in the response against many pathogens, as well as on its remarkable antitumor properties. However, the unexpected toxicity and disappointing results...
5.
Carbajo-Gordillo A, Gonzalez-Cuesta M, Jimenez Blanco J, Benito J, Santana-Armas M, Carmona T, et al.
Chemistry
. 2021 Apr;
27(36):9429-9438.
PMID: 33882160
Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic scaffold allows engineering patchy molecular nanoparticles leveraging directional interactions that emulate those controlling self-assembling processes...
6.
Carbajo-Gordillo A, Jimenez Blanco J, Benito J, Lana H, Marcelo G, Di Giorgio C, et al.
Biomacromolecules
. 2020 Oct;
21(12):5173-5188.
PMID: 33084317
The architectural perfection and multivalency of dendrimers have made them useful for biodelivery via peripheral functionalization and the adjustment of dendrimer generations. Modulation of the core-forming and internal matrix-forming structures...
7.
Neva T, Carbajo-Gordillo A, Benito J, Lana H, Marcelo G, Ortiz Mellet C, et al.
Chemistry
. 2020 Jul;
26(66):15259-15269.
PMID: 32710799
Original molecular vectors that ensure broad flexibility to tune the shape and surface properties of plasmid DNA (pDNA) condensates are reported herein. The prototypic design involves a cyclodextrin (CD) platform...
8.
Barran-Berdon A, Martinez-Negro M, Garcia-Rio L, Domenech O, Tros de Ilarduya C, Aicart E, et al.
J Mater Chem B
. 2020 Apr;
5(17):3122-3131.
PMID: 32263710
The use of divalent cations as mediators between anionic lipids (ALs) and nucleic acids has been explored for several years in gene therapy. However, a promising anionic lipid system which...
9.
Martinez-Negro M, Sanchez-Arribas N, Guerrero-Martinez A, Luisa Moya M, Tros de Ilarduya C, Mendicuti F, et al.
Pharmaceutics
. 2019 Dec;
11(12).
PMID: 31783620
The insertion of biocompatible amino acid moieties in non-viral gene nanocarriers is an attractive approach that has been recently gaining interest. In this work, a cationic lipid, consisting of a...
10.
Martinez-Negro M, Blanco-Fernandez L, Tentori P, Perez L, Pinazo A, Tros de Ilarduya C, et al.
Nanomaterials (Basel)
. 2018 Dec;
8(12).
PMID: 30558369
This work reports the synthesis of a novel gemini cationic lipid that incorporates two histidine-type head groups (C₃(CHis)₂). Mixed with a helper lipid 1,2-dioleoyl--glycero-3-phosphatidyl ethanol amine (DOPE), it was used...