Colton D Payne
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Explore the profile of Colton D Payne including associated specialties, affiliations and a list of published articles.
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13
Citations
39
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Recent Articles
1.
Smallwood T, Krumpe L, Payne C, Klein V, OKeefe B, Clark R, et al.
Chem Sci
. 2024 Aug;
15(33):13227-13233.
PMID: 39183914
The peptide recifin A is the inaugural member of the structurally intriguing new fold referred to as a tyrosine-lock. Its central four stranded β-sheet is stabilized by a unique arrangement...
2.
Wang D, Herzig V, Dekan Z, Rosengren K, Payne C, Hasan M, et al.
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731963
Venom peptides have evolved to target a wide range of membrane proteins through diverse mechanisms of action and structures, providing promising therapeutic leads for diseases, including pain, epilepsy, and cancer,...
3.
Budusan E, Payne C, Gonzalez T, Obergrussberger A, Becker N, Clark R, et al.
Biochem Pharmacol
. 2024 Mar;
228:116175.
PMID: 38552850
Acid-sensing ion channel 1a (ASIC1a) is a proton-gated channel involved in synaptic transmission, pain signalling, and several ischemia-associated pathological conditions. The spider venom-derived peptides PcTx1 and Hi1a are two of...
4.
Payne C, Vadlamani G, Hajiaghaalipour F, Muhammad T, Fisher M, Andersson H, et al.
RSC Chem Biol
. 2022 Jan;
2(6):1682-1691.
PMID: 34977583
Head-to-tail cyclic and disulfide-rich peptides are natural products with applications in drug design. Among these are the PawS-Derived Peptides (PDPs) produced in seeds of the daisy plant family. PDP-23 is...
5.
Gorman D, Li X, Payne C, Cui C, Lee J, Rosengren K, et al.
ACS Pharmacol Transl Sci
. 2021 Dec;
4(6):1808-1817.
PMID: 34927012
The complement activation peptide C5a is a key mediator of inflammation that is associated with numerous immune disorders. C5a binds and activates two seven-transmembrane receptors, C5aR1 and C5aR2. Experimentally, C5a...
6.
Steffen K, Laborde Q, Gunasekera S, Payne C, Rosengren K, Riesgo A, et al.
J Nat Prod
. 2021 Dec;
84(12):3138-3146.
PMID: 34874154
Natural product discovery by isolation and structure elucidation is a laborious task often requiring ample quantities of biological starting material and frequently resulting in the rediscovery of previously known compounds....
7.
Payne C, Fisher M, Mylne J, Rosengren K
J Nat Prod
. 2021 Oct;
84(11):2914-2922.
PMID: 34672199
Plants are an excellent source of bioactive peptides, often with disulfide bonds and/or a cyclic backbone. While focus has predominantly been directed at disulfide-rich peptides, a large family of small,...
8.
Payne C, Franke B, Fisher M, Hajiaghaalipour F, McAleese C, Song A, et al.
Chem Sci
. 2021 May;
12(19):6670-6683.
PMID: 34040741
Head-to-tail cyclized peptides are intriguing natural products with unusual properties. The PawS-Derived Peptides (PDPs) are ribosomally synthesized as part of precursors for seed storage albumins in species of the daisy...
9.
Gorman D, Lee J, Payne C, Woodruff T, Clark R
Amino Acids
. 2021 Jan;
53(1):143-147.
PMID: 33398524
The complement component C5 inhibitory peptide zilucoplan is currently in phase III clinical trials for myasthenia gravis (MG). Despite being at an advanced stage of clinical development, there have been...
10.
Payne C, Vadlamani G, Fisher M, Zhang J, Clark R, Mylne J, et al.
J Nat Prod
. 2020 Sep;
83(10):3030-3040.
PMID: 32997497
Plants and their seeds have been shown to be a rich source of cystine-stabilized peptides. Recently a new family of plant seed peptides whose sequences are buried within precursors for...