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Coloma Costas

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Articles 10
Citations 152
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Recent Articles
1.
Sastre-Dominguez J, DelaFuente J, Toribio-Celestino L, Herencias C, Herrador-Gomez P, Costas C, et al.
Nat Ecol Evol . 2024 Aug; 8(11):2097-2112. PMID: 39198572
Plasmids are extrachromosomal genetic elements commonly found in bacteria. They are known to fuel bacterial evolution through horizontal gene transfer, and recent analyses indicate that they can also promote intragenomic...
2.
Sastre-Dominguez J, DelaFuente J, Toribio-Celestino L, Herencias C, Herrador-Gomez P, Costas C, et al.
bioRxiv . 2024 Jun; PMID: 38903098
Plasmids are extrachromosomal genetic elements commonly found in bacteria. Plasmids are known to fuel bacterial evolution through horizontal gene transfer (HGT), but recent analyses indicate that they can also promote...
3.
DelaFuente J, Toribio-Celestino L, Santos-Lopez A, Leon-Sampedro R, Alonso-Del Valle A, Costas C, et al.
Nat Ecol Evol . 2022 Oct; 6(12):1980-1991. PMID: 36303001
Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key elements in the spread and evolution of AMR in clinical pathogens is the transfer...
4.
Rodriguez-Rosado A, Valencia E, Rodriguez-Rojas A, Costas C, Galhardo R, Rodriguez-Beltran J, et al.
J Antimicrob Chemother . 2019 May; 74(8):2188-2196. PMID: 31102529
Background: Fluoroquinolones such as ciprofloxacin induce the mutagenic SOS response and increase the levels of intracellular reactive oxygen species (ROS). Both the SOS response and ROS increase bacterial mutagenesis, fuelling...
5.
Gil-Marques M, Moreno-Martinez P, Costas C, Pachon J, Blazquez J, McConnell M
J Antimicrob Chemother . 2018 Aug; 73(11):2960-2968. PMID: 30124902
Background: Acinetobacter baumannii is intrinsically resistant to fosfomycin; however, the mechanisms underlying this resistance are poorly understood. Objectives: To identify and characterize genes that contribute to intrinsic fosfomycin resistance in...
6.
Martin-Gutierrez G, Rodriguez-Beltran J, Rodriguez-Martinez J, Costas C, Aznar J, Pascual A, et al.
Antimicrob Agents Chemother . 2016 May; 60(7):4252-8. PMID: 27139482
Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently found in urinary tract infections (UTIs). LLQR mutations are considered the first step in the evolutionary pathway producing high-level...
7.
Rodriguez-Beltran J, Tourret J, Tenaillon O, Lopez E, Bourdelier E, Costas C, et al.
Mol Biol Evol . 2015 Mar; 32(7):1708-16. PMID: 25804522
Homologous recombination promotes genetic diversity by facilitating the integration of foreign DNA and intrachromosomal gene shuffling. It has been hypothesized that if recombination is variable among strains, selection should favor...
8.
Rodriguez-Beltran J, Cabot G, Valencia E, Costas C, Bou G, Oliver A, et al.
Antimicrob Agents Chemother . 2015 Mar; 59(6):3246-51. PMID: 25801561
The modulating effect of N-acetylcysteine (NAC) on the activity of different antibiotics has been studied in Pseudomonas aeruginosa. Our results demonstrate that, in contrast to previous reports, only the activity...
9.
Martinez-Munoz L, Barroso R, Dyrhaug S, Navarro G, Lucas P, Soriano S, et al.
Proc Natl Acad Sci U S A . 2014 Apr; 111(19):E1960-9. PMID: 24778234
CCR5 and CXCR4, the respective cell surface coreceptors of R5 and X4 HIV-1 strains, both form heterodimers with CD4, the principal HIV-1 receptor. Using several resonance energy transfer techniques, we...
10.
Couce A, Briales A, Rodriguez-Rojas A, Costas C, Pascual A, Blazquez J
Antimicrob Agents Chemother . 2012 Feb; 56(5):2767-9. PMID: 22371901
To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a complete set of 5,272 plasmid-expressed open reading frames of Escherichia coli (ASKA collection) was...