Colin R Jefcoate
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Explore the profile of Colin R Jefcoate including associated specialties, affiliations and a list of published articles.
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57
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839
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Recent Articles
1.
Jefcoate C, Larsen M, Song Y, Maguire M, Sheibani N
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076634
substantially affects hepatic vascular and stellate cells (HSC) with linkage to liver fibrosis. Despite minimal hepatocyte expression, deletion substantially impacts liver gene expression at birth and weaning. The appreciable expression...
2.
Larsen M, Rondelli C, Almeldin A, Song Y, Njai A, Alexander D, et al.
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38069208
Polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products converge on the aryl hydrocarbon receptor (AhR) to redirect selective rapid adherence of isolated bone marrow (BM) cells. In young adult mice,...
3.
Song Y, Annalora A, Marcus C, Jefcoate C, Sorenson C, Sheibani N
Cells
. 2022 Oct;
11(19).
PMID: 36230892
Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver, CYP1B1 is predominantly found in extrahepatic tissues, such...
4.
Kothandapani A, Larsen M, Lee J, Jorgensen J, Jefcoate C
Mol Cell Endocrinol
. 2021 Apr;
531:111265.
PMID: 33864885
STARD1 stimulates cholesterol transfer to mitochondrial CYP11A1 for conversion to pregnenolone. A cholesterol-binding START domain is guided by an N-terminal domain in a cell selective manner. Fetal and adult Leydig...
5.
Kothandapani A, Jefcoate C, Jorgensen J
Endocrinology
. 2021 Mar;
162(7).
PMID: 33784378
Two specialized functions of cholesterol during fetal development include serving as a precursor to androgen synthesis and supporting hedgehog (HH) signaling activity. Androgens are produced by the testes to facilitate...
6.
Larsen M, Lee J, Jorgensen J, Jefcoate C
Front Endocrinol (Lausanne)
. 2020 Nov;
11:559674.
PMID: 33193082
STARD1 moves cholesterol (CHOL) from the outer mitochondrial membrane (OMM) to the inner membrane (IMM) in steroidogenic cells. This activity is integrated into CHOL trafficking and synthesis homeostasis, involving uptake...
7.
Larsen M, Almeldin A, Tong T, Rondelli C, Maguire M, Jaskula-Sztul R, et al.
Toxicol Appl Pharmacol
. 2020 Jun;
401:115111.
PMID: 32553695
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). This metabolism occurs in bone marrow (BM) mesenchymal stem cells...
8.
Falero-Perez J, Larsen M, Teixeira L, Zhang H, Lindner V, Sorenson C, et al.
Trends Dev Biol
. 2020 Apr;
12:1-12.
PMID: 32255961
Mutations in cytochrome P450 1B1 (CYP1B1) gene are reported in patients with primary congenital glaucoma. -deficient (-/-) mice show dysgenesis of the trabecular meshwork (TM) tissue and attenuation of retinal...
9.
Maguire M, Larsen M, Vezina C, Quadro L, Kim Y, Tanumihardjo S, et al.
PLoS One
. 2020 Feb;
15(2):e0228436.
PMID: 32027669
Background: Cytochrome P450 1b1 (Cyp1b1) deletion and dietary retinol deficiency during pregnancy (GVAD) affect perinatal liver functions regulated by Srebp. Cyp1b1 is not expressed in perinatal liver but appears in...
10.
Day J, Nicholson T, Su X, van Neel T, Clinton I, Kothandapani A, et al.
Lab Chip
. 2019 Nov;
20(1):107-119.
PMID: 31712791
Open microfluidic cell culture systems are powerful tools for interrogating biological mechanisms. We have previously presented a microscale cell culture system, based on spontaneous capillary flow of biocompatible hydrogels, that...