Colin Pritchard
Overview
Explore the profile of Colin Pritchard including associated specialties, affiliations and a list of published articles.
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95
Citations
2467
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Recent Articles
1.
Wang Y, Gan C, Beukers-Korver J, Rosing H, Li W, Wagenaar E, et al.
Acta Pharmacol Sin
. 2024 Nov;
46(3):777-793.
PMID: 39496863
Carboxylesterase 2 (CES2) is expressed mainly in liver and intestine, but most abundantly in intestine. It hydrolyzes carboxylester, thioester, and amide bonds in many exogenous and endogenous compounds, including lipids....
2.
Frank S, Persse T, Coleman I, Bankhead 3rd A, Li D, De-Sarkar N, et al.
bioRxiv
. 2024 Jul;
PMID: 39071291
Genomic loss of the transcriptional kinase occurs in ~6% of metastatic castration-resistant prostate cancers (mCRPC) and correlates with poor patient outcomes. Prior studies demonstrate that acute CDK12 loss confers a...
3.
Pritchard C, Silk A, Hansen L, Panesar H, Berendt T
J Neurol Sci
. 2024 Jun;
462:123094.
PMID: 38897154
Objective: We examine whether the rise in neurological death rates over the 21st century are solely explained by the Gompertzian hypothesis. Study Design: We examine two data-sets. First, Office of...
4.
Tung N, Ricker C, Messersmith H, Balmana J, Domchek S, Stoffel E, et al.
J Clin Oncol
. 2024 May;
42(21):2599-2615.
PMID: 38759122
Purpose: To guide use of multigene panels for germline genetic testing for patients with cancer. Methods: An ASCO Expert Panel convened to develop recommendations on the basis of a systematic...
5.
Pritchard C, Abdul Azeez E, Mirza S
Health Care Women Int
. 2023 Jul;
46(3):278-295.
PMID: 37450643
In this study, we examined health inequalities and the status of women as evidenced in the patterns of population and mortality statistics in fifteen Muslim-populated countries. Based on WHO data,...
6.
Gan C, Wang J, Martinez-Chavez A, Hillebrand M, de Vries N, Beukers J, et al.
Acta Pharm Sin B
. 2023 Mar;
13(2):618-631.
PMID: 36873183
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated cluster knockout...
7.
Wyszkowska J, Pritchard C
Int J Environ Res Public Health
. 2022 Dec;
19(23).
PMID: 36498223
This work presents the current state of knowledge about the possible contributory influence of the electromagnetic field on the occurrence of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, amyotrophic...
8.
Ordering and Interpreting Precision Oncology Studies for Adults With Advanced Solid Tumors: A Primer
Montgomery B, Wang S, Rettig M, Lee B, Bates J, Pritchard C
Fed Pract
. 2022 Aug;
39(Suppl 2):S16-S24.
PMID: 35929009
Background: The promise of precision oncology can only be realized when genetic alterations are identified that can be leveraged to improve response and minimize toxicity. Identifying those alterations requires the...
9.
Spanjaard A, Shah R, de Groot D, Buoninfante O, Morris B, Lieftink C, et al.
Nucleic Acids Res
. 2022 Jul;
50(13):7420-7435.
PMID: 35819193
Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis...
10.
Chen W, Pao E, Owens J, Glass I, Pritchard C, Shirts B, et al.
Cold Spring Harb Mol Case Stud
. 2022 Apr;
8(3).
PMID: 35483878
The megalencephaly-capillary malformation (MCAP) syndrome is an overgrowth disorder caused by mosaic gain-of-function variants in It is characterized by megalencephaly or hemimegalencephaly, vascular malformations, somatic overgrowth, among other features. Epilepsy...