Colin K L Phoon
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Explore the profile of Colin K L Phoon including associated specialties, affiliations and a list of published articles.
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66
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1193
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Recent Articles
1.
Phoon C, Aristizabal O, Farhoud M, Turnbull D, Wadghiri Y
Curr Protoc
. 2024 Sep;
4(9):e1116.
PMID: 39222027
The mouse is the mammalian model of choice for investigating cardiovascular biology, given our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental means. Imaging is an important approach...
2.
Sachan N, Phoon C, Bu L, Zilberberg L, Ahamed J, Rifkin D
Matrix Biol Plus
. 2024 Jun;
22:100149.
PMID: 38831847
Although the mechanism for activation of latent TGFβ1 and TGFβ3 is understood to involve the binding of the TGFβ propeptide (LAP) to both an integrin and an insoluble substrate, the...
3.
Trostle M, Grossman T, Penfield C, Phoon C, Raabe V, Sloane M, et al.
AJP Rep
. 2024 Feb;
14(1):e66-e68.
PMID: 38370327
Multisystem inflammatory syndrome in children (MIS-C), a new condition related to coronavirus disease 2019 (COVID-19) in the pediatric population, was recognized by physicians in the United Kingdom in April 2020....
4.
Yamaguchi N, Chang E, Lin Z, Shekhar A, Bu L, Khodadadi-Jamayran A, et al.
Circulation
. 2023 Sep;
148(21):1705-1722.
PMID: 37772400
Background: Conotruncal defects due to developmental abnormalities of the outflow tract (OFT) are an important cause of cyanotic congenital heart disease. Dysregulation of transcriptional programs tuned by NKX2-5 (NK2 homeobox...
5.
Ren M, Xu Y, Phoon C, Erdjument-Bromage H, Neubert T, Schlame M
J Biol Chem
. 2023 Sep;
299(10):105241.
PMID: 37690688
Respiratory complexes and cardiolipins have exceptionally long lifetimes. The fact that they co-localize in mitochondrial cristae raises the question of whether their longevities have a common cause and whether the...
6.
Sachan N, Phoon C, Zilberberg L, Kugler M, Ene T, Mintz S, et al.
Matrix Biol
. 2023 May;
121:41-55.
PMID: 37217119
To assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome (MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the gene defective in...
7.
Makadia L, Izmirly P, Buyon J, Phoon C
AJP Rep
. 2023 May;
13(2):e29-e34.
PMID: 37168107
Maternal anti-Ro (SSA) and/or anti-La (SSB) antibodies are a risk factor for congenital complete heart block (CHB). Because detailed analysis of the incidence of CHB after 24 weeks of gestational...
8.
Minocha P, Srinivasan R, Babb J, Singh R, Phoon C, Better D, et al.
Ann Pediatr Cardiol
. 2023 May;
15(5-6):459-466.
PMID: 37152504
Context: Cardiac injury has been described in both acute COVID-19 and the multisystem inflammatory syndrome in children (MIS-C). Echocardiographic strain has been shown to be a sensitive measure of systolic...
9.
Singh N, Ren M, Phoon C
J Cardiovasc Dev Dis
. 2023 Apr;
10(4).
PMID: 37103033
Background: Although the heart requires abundant energy, only 20-40% of children with mitochondrial diseases have cardiomyopathies. Methods: We looked for differences in genes underlying mitochondrial diseases that do versus do...
10.
Ren M, Xu Y, Phoon C, Erdjument-Bromage H, Neubert T, Schlame M
bioRxiv
. 2023 Mar;
PMID: 36945411
Background: Cardiomyocyte maturation requires a massive increase in respiratory enzymes and their assembly into long-lived complexes of oxidative phosphorylation (OXPHOS). The molecular mechanisms underlying the maturation of cardiac mitochondria have...