Colin Flinders
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Explore the profile of Colin Flinders including associated specialties, affiliations and a list of published articles.
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5
Citations
81
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Recent Articles
1.
Liu X, Lukowski J, Flinders C, Kim S, Georgiadis R, Mumenthaler S, et al.
Anal Chem
. 2018 Nov;
90(24):14156-14164.
PMID: 30479121
Immunotherapies are treatments that use a patient's immune system to combat disease. One important type of immunotherapy employed in cancer treatments is the delivery of monoclonal antibodies to block growth...
2.
Liu X, Flinders C, Mumenthaler S, Hummon A
J Am Soc Mass Spectrom
. 2017 Dec;
29(3):516-526.
PMID: 29209911
Patient-derived colorectal tumor organoids (CTOs) closely recapitulate the complex morphological, phenotypic, and genetic features observed in in vivo tumors. Therefore, evaluation of drug distribution and metabolism in this model system...
3.
Yadav V, Smith K, Flinders C, Mumenthaler S, De S
Sci Rep
. 2016 Jun;
6:27437.
PMID: 27272679
Functional mutations in coding regions not only affect the structure and function of the protein products, but may also modulate their expression in some cases. This class of mutations, recently...
4.
Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen P, et al.
Genome Med
. 2016 May;
8(1):54.
PMID: 27146673
Background: The genetic origins of chemotherapy resistance are well established; however, the role of epigenetics in drug resistance is less well understood. To investigate mechanisms of drug resistance, we performed...
5.
Frieboes H, Smith B, Wang Z, Kotsuma M, Ito K, Day A, et al.
PLoS One
. 2015 Jun;
10(6):e0129433.
PMID: 26061425
We combine mathematical modeling with experiments in living mice to quantify the relative roles of intrinsic cellular vs. tissue-scale physiological contributors to chemotherapy drug resistance, which are difficult to understand...