Colin D Paul
Overview
Explore the profile of Colin D Paul including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
873
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0
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Recent Articles
1.
Yankaskas C, Thompson K, Paul C, Vitolo M, Mistriotis P, Mahendra A, et al.
Nat Biomed Eng
. 2025 Feb;
9(2):285.
PMID: 39910377
No abstract available.
2.
Paul C, Yankaskas C, Shahi Thakuri P, Balhouse B, Salen S, Bullock A, et al.
Sci Rep
. 2025 Jan;
15(1):3933.
PMID: 39890889
Tumoroids, sometimes referred to as cancer organoids, are patient-derived cancer cells grown as 3D, self-organized multicellular structures that maintain key characteristics (e.g., genotype, gene expression levels) of the tumor from...
3.
So W, Wong C, Azubuike U, Paul C, Rezvan Sangsari P, Gordon P, et al.
bioRxiv
. 2023 Dec;
PMID: 38076880
Biophysical profiling of primary tumors has revealed that individual tumor cells fall along a highly heterogeneous continuum of mechanical phenotypes. One idea is that a subset of tumor cells is...
4.
Bera K, Kiepas A, Godet I, Li Y, Mehta P, Ifemembi B, et al.
Nature
. 2022 Nov;
611(7935):365-373.
PMID: 36323783
Cells respond to physical stimuli, such as stiffness, fluid shear stress and hydraulic pressure. Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such...
5.
Paul C, Bishop K, Devine A, Paine E, Staunton J, Thomas S, et al.
Cell Syst
. 2019 Aug;
9(2):187-206.e16.
PMID: 31445892
Tumor cells encounter a myriad of physical cues upon arrest and extravasation in capillary beds. Here, we examined the role of physical factors in non-random organ colonization using a zebrafish...
6.
Staunton J, So W, Paul C, Tanner K
Proc Natl Acad Sci U S A
. 2019 Jul;
116(29):14448-14455.
PMID: 31266897
Mechanical homeostasis describes how cells sense physical cues from the microenvironment and concomitantly remodel both the cytoskeleton and the surrounding extracellular matrix (ECM). Such feedback is thought to be essential...
7.
Yankaskas C, Thompson K, Paul C, Vitolo M, Mistriotis P, Mahendra A, et al.
Nat Biomed Eng
. 2019 May;
3(6):452-465.
PMID: 31061459
The challenge of predicting which patients with breast cancer will develop metastases leads to the overtreatment of patients with benign disease and to the inadequate treatment of aggressive cancers. Here,...
8.
Paul C, Devine A, Bishop K, Xu Q, Wulftange W, Burr H, et al.
Sci Rep
. 2019 Feb;
9(1):1759.
PMID: 30741975
The inflammatory response, modulated both by tissue resident macrophages and recruited monocytes from peripheral blood, plays a critical role in human diseases such as cancer and neurodegenerative disorders. Here, we...
9.
Paul C, Hruska A, Staunton J, Burr H, Daly K, Kim J, et al.
Biomaterials
. 2019 Jan;
197:101-118.
PMID: 30641262
Biophysical aspects of in vivo tissue microenvironments include microscale mechanical properties, fibrillar alignment, and architecture or topography of the extracellular matrix (ECM). These aspects act in concert with chemical signals...
10.
Paul C, Mistriotis P, Konstantopoulos K
Nat Rev Cancer
. 2016 Dec;
17(2):131-140.
PMID: 27909339
Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features...