Colby L Eaton
Overview
Explore the profile of Colby L Eaton including associated specialties, affiliations and a list of published articles.
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27
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1145
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Recent Articles
1.
Brown H, Allocca G, Ottewell P, Wang N, Brown N, Croucher P, et al.
Int J Mol Sci
. 2018 Sep;
19(10).
PMID: 30261597
Breast cancer cells colonize the skeleton by homing to specific niches, but the involvement of osteoblasts in tumour cell seeding, colonization, and progression is unknown. We used an in vivo...
2.
Alshaibi H, Ahmed F, Buckle C, Fowles A, Awlia J, Cecchini M, et al.
Biotechnol Appl Biochem
. 2017 Oct;
65(3):407-418.
PMID: 28981962
Bone metastasis is a key event responsible for morbidity in prostate cancer patients. Interactions between prostate cancer cells and the bone microenvironment facilitate survival of tumor cells and alter bone...
3.
Lawson M, McDonald M, Kovacic N, Khoo W, Terry R, Down J, et al.
Nat Commun
. 2015 Dec;
6:8983.
PMID: 26632274
Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist...
4.
Wang N, Reeves K, Brown H, Fowles A, Docherty F, Ottewell P, et al.
J Exp Clin Cancer Res
. 2015 Oct;
34:124.
PMID: 26480944
Background: While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a...
5.
Evans C, Glen A, Eaton C, Larre S, Catto J, Hamdy F, et al.
Proteomics Clin Appl
. 2015 Aug;
3(2):197-212.
PMID: 26238619
Prostate cancer (PCa) is the most common cancer diagnosis and the second most common cause of cancer-related deaths in men. Currently, serum prostate-specific antigen (PSA) is the only biomarker widely...
6.
Wang N, Docherty F, Brown H, Reeves K, Fowles A, Lawson M, et al.
FASEB J
. 2015 Apr;
29(8):3141-50.
PMID: 25888599
This study aimed to identify subpopulations of prostate cancer cells that are responsible for the initiation of bone metastases. Using rapidly dividing human prostate cancer cell lines, we identified mitotically...
7.
Ottewell P, Wang N, Brown H, Fowles C, Croucher P, Eaton C, et al.
Int J Cancer
. 2015 Jan;
137(4):968-77.
PMID: 25603921
Dormant disseminated tumour cells can be detected in the bone marrow of breast cancer patients several years after resection of the primary tumour. The majority of these patients will remain...
8.
Reeves K, Hurrell J, Cecchini M, van der Pluijm G, Down J, Eaton C, et al.
Int J Cancer
. 2014 Aug;
136(7):1731-40.
PMID: 25156971
Micrometastasis is a barrier to the development of effective cancer therapies for prostate cancer metastasis to bone. The mechanisms remain incompletely characterised, primarily due to an inability to adequately monitor...
9.
Ottewell P, Wang N, Meek J, Fowles C, Croucher P, Eaton C, et al.
Endocr Relat Cancer
. 2014 Jul;
21(5):769-81.
PMID: 25052474
Up to 90% of patients with castrate-resistant prostate cancer develop bone metastases, and the majority of these men have received androgen deprivation therapy known to cause bone loss. Whether this...
10.
Wang N, Docherty F, Brown H, Reeves K, Fowles A, Ottewell P, et al.
J Bone Miner Res
. 2014 Jun;
29(12):2688-96.
PMID: 24956445
It has been suggested that metastasis-initiating cells gain a foothold in bone by homing to a metastastatic microenvironment (or "niche"). Whereas the precise nature of this niche remains to be...