Clement M Lee
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Explore the profile of Clement M Lee including associated specialties, affiliations and a list of published articles.
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18
Citations
281
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Recent Articles
1.
Lee C, Aizawa K, Jiang J, Kung S, Jain R
Sci Adv
. 2019 Dec;
5(8):eaav0318.
PMID: 31803841
JLP belongs to the JIP family whose members serve as scaffolding proteins that link motor proteins and their cargo for intracellular transport. Although JLP is mainly cytoplasmic, it accumulates as...
2.
Wang Y, Cheng X, Samma M, Kung S, Lee C, Chiu S
Mol Cell Biochem
. 2017 Dec;
443(1-2):193-204.
PMID: 29188535
c-Myc is a highly pleiotropic transcription factor known to control cell cycle progression, apoptosis, and cellular transformation. Normally, ectopic expression of c-Myc is associated with promoting cell proliferation or triggering...
3.
Lee C
J Vis Exp
. 2016 Mar;
(108):53632.
PMID: 26966786
Fluorescence microscopy is employed to identify Kinesin-1 cargos. Recently, the heavy chain of Kinesin-1 (KIF5B) was shown to transport the nuclear transcription factor c-MYC for proteosomal degradation in the cytoplasm....
4.
Ramkumar P, Lee C, Moradian A, Sweredoski M, Hess S, Sharrocks A, et al.
J Biol Chem
. 2015 Oct;
290(49):29617-28.
PMID: 26468278
JLP (JNK-associated leucine zipper protein) is a scaffolding protein that interacts with various signaling proteins associated with coordinated regulation of cellular process such as endocytosis, motility, neurite outgrowth, cell proliferation,...
5.
Lee C
Biochim Biophys Acta
. 2014 May;
1843(9):2027-36.
PMID: 24821626
c-MYC is an oncogenic transcription factor that is degraded by the proteasome pathway. However, the mechanism that regulates delivery of c-MYC to the proteasome for degradation is not well characterized....
6.
Wang H, Zhao C, Zhang M, Lee C, Reddy E, Kung S
Immunobiology
. 2012 Nov;
218(6):835-43.
PMID: 23182713
Receptor internalization is a common mechanism underlying surface receptor down-regulation (and thus receptor signaling) upon its engagement with the cognate ligand. Tight regulation of surface CD40 expression is critical in...
7.
Reddy M, Akula B, Cosenza S, Lee C, Mallireddigari M, Pallela V, et al.
J Med Chem
. 2012 May;
55(11):5174-87.
PMID: 22587519
Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-aryl-3-arylamino-2-propen-1-one (10) were synthesized and evaluated for antiproliferative activity in cell-based...
8.
Kashef K, Radhakrishnan R, Lee C, Reddy E, Dhanasekaran D
Neoplasia
. 2011 Apr;
13(4):358-64.
PMID: 21472140
The activated mutants of the α-subunits of G proteins G(12) and G(13) have been designated as the gep oncogenes owing to their ability to stimulate diverse oncogenic signaling pathways that...
9.
Xu H, Dhanasekaran D, Lee C, Reddy E
J Biol Chem
. 2009 Dec;
285(6):3548-3553.
PMID: 19959466
JLP (JNK-associated leucine zipper protein) is a novel scaffolding protein involved in JNK signaling. Although it is known that JLP is highly expressed in brain, the biological function of JLP...
10.
Ji R, Lee C, Gonzales L, Yang Y, Aksoy M, Wang P, et al.
Am J Physiol Lung Cell Mol Physiol
. 2008 Apr;
294(6):L1187-96.
PMID: 18375741
Chemokine receptors control several fundamental cellular processes in both hematopoietic and structural cells, including directed cell movement, i.e., chemotaxis, cell differentiation, and proliferation. We have previously demonstrated that CXCR3, the...